Results 131 to 140 of about 1,912,865 (328)

Harnessing decay rates for coastal marine biosecurity applications: A review of environmental DNA and RNA fate [PDF]

, 2023
Michelle Scriver, Anastasija Zaiko, Xavier Pochon, Ulla von Ammon   +3 more
openalex   +1 more source

Treatment with integrase inhibitor suggests a new interpretation of HIV RNA decay curves that reveals a subset of cells with slow integration

PLoS Pathogens, 2017
The kinetics of HIV-1 decay under treatment depends on the class of antiretrovirals used. Mathematical models are useful to interpret the different profiles, providing quantitative information about the kinetics of virus replication and the cell ...
E. F. Cardozo, A. Andrade, J. Mellors, D. Kuritzkes, A. Perelson, R. Ribeiro, R. Ribeiro   +6 more
semanticscholar   +1 more source

Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity

Advanced Healthcare Materials, EarlyView.
This study presents the first human neural organoid culture model capable of rapidly exhibiting long‐distance neural network propagation, thus delivering a system to experimentally investigate large‐scale communication during normal and diseased states.
Megh Dipak Patel, Sailee Sham Lavekar, Ronak Jaisalmeria, Suki Oji, Jazmine Jayasi, Caroline Cvetkovic, Robert Krencik   +6 more
wiley   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

RNA decay defines the response to transcriptional perturbation in leukaemia [PDF]

, 2022
Izabela Todorovski, Breon Feran, Zheng Fan, Sreeja Gadipally, David Yoannidis, Isabella Y. Kong, Stefan Bjelosevic, Magnus Zethoven, Edwin D. Hawkins, Kaylene J. Simpson, Gisela Mir Arnau, Anthony T. Papenfuss, Ricky W. Johnstone, Stephin J. Vervoort   +13 more
openalex   +1 more source

Enhancing Magnetic Hyperthermia at the Cell Membrane by Anchoring 92R‐Functionalized Magnetic Nanoparticles to Low‐Endocytic CCR9 Surface Receptors

Advanced Healthcare Materials, EarlyView.
We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente, Isabel Corraliza‐Gorjón, Thomas S. van Zanten, María del Puerto Morales, Leonor Kremer, Domingo F. Barber   +5 more
wiley   +1 more source

Multiple decay events target HAC1 mRNA during splicing to regulate the unfolded protein response

eLife, 2019
In the unfolded protein response (UPR), stress in the endoplasmic reticulum (ER) activates a large transcriptional program to increase ER folding capacity.
Patrick D Cherry, Sally E Peach, Jay R Hesselberth   +2 more
doaj   +1 more source

Supplementary methods from Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring <i>SF3B1</i> or <i>U2AF1</i> Mutations

, 2023
Abigael Cheruiyot, Shan Li, Sridhar Nonavinkere Srivatsan, Tanzir Ahmed, Yuhao Chen, Delphine S. Lemacon, Ying Li, Zheng Yang, Brian A. Wadugu, Wayne A. Warner, Shondra M. Pruett‐Miller, Esther A. Obeng, Daniel C. Link, Dalin He, Fei Xiao, Xiaowei Wang, Julie M. Bailis, Matthew J. Walter, Zhongsheng You   +18 more
openalex   +1 more source

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

Nature Structural &Molecular Biology, 2016
Mutations in the human telomerase RNA component (hTR), the telomerase ribonucleoprotein component dyskerin (DKC1) and the poly(A) RNase (PARN) can lead to reduced levels of hTR and to dyskeratosis congenita (DC).
S. Shukla, Jens C. Schmidt, Katherine C. Goldfarb, T. Cech, R. Parker   +4 more
semanticscholar   +1 more source

SiO2‐CaOCME/Poly(Tetrahydrofuran)/Poly(Caprolactone) 3D‐Printed Scaffolds Drive Human‐Bone Marrow Stromal Cell Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
3D printed hybrid scaffolds combining bioactive silica–calcium chemistry with elastic polymers guide human bone stem cells to form bone. The scaffolds support cell survival, organization, and invasion while releasing osteogenic ions. Together, architecture and composition drive bone‐specific gene expression, extracellular matrix organization, and ...
David R. Sory, Agathe C.M. Heyraud, Julian R. Jones, Sara M. Rankin   +3 more
wiley   +1 more source