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RNA decay mechanisms: Specificity through diversity
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013no ...
Georg, Stoecklin, Oliver, Mühlemann
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Messenger RNA decay and protection
Journal of Molecular Biology, 1964The decay of messenger RNA in Bacillus subtilis has been studied under a variety of conditions which interfere with protein synthesis. Changes in the growth rate produced by altering the medium do not affect the proportion of messenger relative to total RNA.
D P, FAN, A, HIGA, C, LEVINTHAL
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Targeting of viral RNAs by Upf1-mediated RNA decay pathways
Current Opinion in Virology, 2021Viral RNAs are susceptible to co-translational RNA decay pathways mediated by the RNA helicase Upstream frameshift 1 (Upf1). Upf1 is a key component in nonsense-mediated decay (NMD), Staufen1-mediated mRNA decay (SMD), and structure-mediated RNA decay (SRD) pathways, among others.
Jared P May, Anne E Simon
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RNA decay by messenger RNA interferases.
Methods in enzymology, 2008Two abundant toxin-antitoxin (TA) gene families, relBE and mazEF, encode mRNA cleaving enzymes whose ectopic overexpression abruptly inhibits translation and thereby induces a bacteriostatic condition. Here we describe and discuss protocols for the overproduction, purification, and analysis of mRNA cleaving enzymes such as RelE of Escherichia coli and ...
Christensen-Dalsgaard M +3 more
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RNA processing and decay in plastids
WIREs RNA, 2013AbstractPlastids were derived through endosymbiosis from a cyanobacterial ancestor, whose uptake was followed by massive gene transfer to the nucleus, resulting in the compact size and modest coding capacity of the extant plastid genome. Plastid gene expression is essential for plant development, but depends on nucleus‐encoded proteins recruited from ...
Arnaud, Germain +3 more
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EcoSal Plus, 2007
This chapter discusses several topics relating to the mechanisms of mRNA decay. These topics include the following: important physical properties of mRNA molecules that can alter their stability; methods for determining mRNA half-lives; the genetics and biochemistry of proteins and enzymes involved in mRNA decay; posttranscriptional ...
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This chapter discusses several topics relating to the mechanisms of mRNA decay. These topics include the following: important physical properties of mRNA molecules that can alter their stability; methods for determining mRNA half-lives; the genetics and biochemistry of proteins and enzymes involved in mRNA decay; posttranscriptional ...
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The exosome: a multipurpose RNA-decay machine
Trends in Biochemical Sciences, 2008The diversity of RNAs in the cell continues to amaze. In addition to the 'classic' species of mRNA, tRNA, rRNA, snRNA and snoRNA, it is now clear that the majority of genomic information is transcribed into RNA molecules. The resulting complexity of the transcriptome poses a serious challenge to cells because they must manage numerous RNA-processing ...
Schmid, Manfred, Jensen, Torben Heick
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Nature Neuroscience, 2007
Lasting synaptic plasticity requires precise local regulation of protein expression. A recent paper reports that the postsynaptic activity–induced arc mRNA is a target for rapid degradation by the 'nonsense-mediated decay' pathway.
Carol L Peebles, Steven Finkbeiner
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Lasting synaptic plasticity requires precise local regulation of protein expression. A recent paper reports that the postsynaptic activity–induced arc mRNA is a target for rapid degradation by the 'nonsense-mediated decay' pathway.
Carol L Peebles, Steven Finkbeiner
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The Decay of Bacterial Messenger RNA
1996Publisher Summary The many demonstrations that the Escherichia coli (E. coli ) rne gene product (RNase E) is involved in messenger RNA (mRNA) decay have given real impetus to the study of this unusual protein's properties and role. The recent attention given to the polyadenylylation of bacterial mRNAs and the discovery that polyadenylylation ...
D P, Nierlich, G J, Murakawa
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Nonsense mediated RNA decay and evolutionary capacitance
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016Nonsense mediated RNA decay (NMD) is well-known as an RNA quality control mechanism that sequesters a substantial portion of RNA from expression by targeting it for degradation. However, a number of recent studies across a range of organisms indicate a broader role for NMD in gene regulation and transcriptome homeostasis.
Vivek Kumar, Raxwal, Karel, Riha
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