Results 161 to 170 of about 218,010 (194)
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Viral RNAs versus the Cellular RNA Decay Machinery
Microbe Magazine, 2014Understanding the interactions between RNA viruses and the cellular mRNA decay machinery can yield important insights into the biology of many families of viruses and their host cells and may provide novel pathways for drug design. Viral suppression of host cellular exonucleases and the sponging of host stability factors also seem to be crucial for ...
Stephanie L. Moon, Jeffrey Wilusz
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HUSH, retrotransposon RNA, you’re NEXT to decay
Molecular Cell, 2022Garland et al. (2022) discover a physical and functional connection between the HUSH silencing complex and the NEXT nuclear RNA decay complex in mouse embryonic stem cells and conclude HUSH recruits NEXT to degrade prematurely terminated retrotransposon RNAs.
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Decay of RNA in RNA processing mutants of Escherichia coli
Molecular and General Genetics MGG, 1980Stability of RNA was tested in strains of Escherichia coli carrying single, double, or triple mutations in the RNA processing enzymes RNase III, RNase E and RNase P. Tests were carried out for total pulse labeled RNA, beta-galactosidase mRNA and for the decay of preexisting RNA during carbon starvation.
D, Apirion, D R, Gitelman
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The Nonsense-Mediated Decay RNA Surveillance Pathway
Annual Review of Biochemistry, 2007Nonsense-mediated mRNA decay (NMD) is a quality-control mechanism that selectively degrades mRNAs harboring premature termination (nonsense) codons. If translated, these mRNAs can produce truncated proteins with dominant-negative or deleterious gain-of-function activities. In this review, we describe the molecular mechanism of NMD.
Yao-Fu, Chang +2 more
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Out or decay: fate determination of nuclear RNAs
Essays in Biochemistry, 2020Abstract In eukaryotes, RNAs newly synthesized by RNA polymerase II (RNAPII) undergo several processing steps prior to transport to the cytoplasm. It has long been known that RNAs with defects in processing or export are removed in the nucleus.
Jianshu Wang, Hong Cheng
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Messenger RNA decay during aging and development
Ageing Research Reviews, 2002Gene expression is a combination of many processes, including transcription, pre-mRNA processing, nucleocytoplasmic transport of mRNA, translation, mRNA decay, and protein modification and decay. Many changes in the programs of gene expression occur during development, differentiation, and aging.
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RNA deadenylation and decay in plants
Journal of Plant Biology, 2013In eukaryotic cells, RNA levels are tightly regulated in a spatio-temporal manner to maintain the protein levels necessary for cell growth, differentiation and division. To cope with developmental and rapid environmental changes, RNAs that are no longer required by the cell undergo degradation via the mRNA decay process. A number of players involved in
Nazia Abbasi +2 more
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Poly(A)-assisted RNA decay and modulators of RNA stability.
Progress in molecular biology and translational science, 2009In Escherichia coli, RNA degradation is orchestrated by the degradosome with the assistance of complementary pathways and regulatory cofactors described in this chapter. They control the stability of each transcript and regulate the expression of many genes involved in environmental adaptation.
Ph., Régnier, Hajnsdorf, E.
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Cellular functions of eukaryotic RNA helicases and their links to human diseases
Nature Reviews Molecular Cell Biology, 2023Katherine E Bohnsack +2 more
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