Results 41 to 50 of about 206,980 (316)
RNA Decay by the Eukaryotic Exosome [PDF]
Biophysical Journal, 2009 The eukaryotic RNA exosome is a multi-subunit protein complex that regulates RNA processing and decay in processes that maintain the quality and abundance of cellular RNA. The subunit composition and activities of eukaryotic exosomes were determined by reconstituting exosomes from yeast and human.
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MARVELD1 Inhibits Nonsense-Mediated RNA Decay by Repressing Serine Phosphorylation of UPF1. [PDF]
PLoS ONE, 2013 We have observed low expression levels of MARVELD1, a novel tumor repressor, in multiple tumors; however, its function in normal cells has not been explored.
Jianran Hu, Yu Li, Ping Li
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Interaction Between LncRNA and UPF1 in Tumors
Frontiers in Genetics, 2021 Long non-coding RNAs (LncRNAs) can bind to other proteins or RNAs to regulate gene expression, and its role in tumors has been extensively studied. A common RNA binding protein, UPF1, is also a key factor in a variety of RNA decay pathways.
Junjian He +3 more
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Low-energy neutrino physics and neutrino mass [PDF]
, 1984 Among the principal concerns in neutrino physics today are the questions of whether neutrinos are massive and, if so, whether the neutrinos emitted in a weak decay are pure or mixed quantum states. The concept of mixed neutrinos has been with us for more
Boehm, F., Vogel, P.
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PLoS Pathogens, 2019 Nuclear RNAs are subject to a number of RNA decay pathways that serve quality control and regulatory functions. As a result, any virus that expresses its genes in the nucleus must have evolved mechanisms that avoid these pathways, but the how viruses ...
Julio C Ruiz +2 more
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Impact of nonsense-mediated mRNA decay on the global expression profile of budding yeast. [PDF]
PLoS Genetics, 2006 Nonsense-mediated mRNA decay (NMD) is a eukaryotic mechanism of RNA surveillance that selectively eliminates aberrant transcripts coding for potentially deleterious proteins. NMD also functions in the normal repertoire of gene expression.
Qiaoning Guan +7 more
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Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing
Frontiers in Endocrinology, 2021 Mounting evidence suggests a role for alternative splicing (AS) of transcripts in the normal physiology and pathophysiology of the pancreatic β-cell. In the apparent absence of RNA repair systems, RNA decay pathways are likely to play an important role ...
Seyed M. Ghiasi, Guy A. Rutter
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Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia [PDF]
, 2015 Long non-coding RNAs (lncRNAs) are important regulators of gene expression that influence almost every step in the life cycle of genes, from transcription to mRNA splicing, RNA decay, and translation.
Ballarino, Monica +2 more
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Engineered viral RNA decay intermediates to assess XRN1-mediated decay [PDF]
Methods, 2019 Both RNA synthesis and decay must be balanced within a cell to achieve proper gene expression. Additionally, modulation of RNA decay specifically offers the cell an opportunity to rapidly reshape the transcriptome in response to specific stimuli or cues.
Phillida A. Charley +4 more
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RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent [PDF]
BioEssays, 2017 The RNA‐binding protein, UPF1, is best known for its central role in the nonsense‐mediated RNA decay (NMD) pathway. Feng et al. now report a new function for UPF1—it is an E3 ubiquitin ligase that specifically promotes the decay of a key pro‐muscle transcription factor: MYOD.
Plank, Terra‐Dawn M +1 more
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