Results 201 to 210 of about 509,868 (288)

Sofosbuvir: A Potential Treatment for Ebola

Frontiers in Pharmacology, 2018
Sandra E. Reznik, Sandra E. Reznik, Amit K. Tiwari, Charles R. Ashby   +3 more
doaj   +1 more source

Dual-Site Inhibition of SARS-CoV-2 RNA-Dependent RNA Polymerase by Small Molecules Able to Block Viral Replication Identified through a Computer-Aided Drug Discovery Approach. [PDF]

ACS Infect Dis
Malune P, Iaconis D, Manelfi C, Giunta S, Emmolo R, Lunghini F, Paulis A, Talarico C, Corona A, Beccari AR, Tramontano E, Esposito F.   +11 more
europepmc   +1 more source

Immunological studies on plant DNA-dependent RNA polymerases with antibodies raised against individual subunits.

, 1984
Tom J. Guilfoyle, Gretchen Hagen, S Malcolm   +2 more
openalex   +1 more source

Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase

, 2020
Aïcha Gharbi-Ayachi, Sridhar Santhanakrishnan, Yee Hwa Wong, Kitti Wing Ki Chan, Siok Thing Tan, Roderick W. Bates, Subhash G. Vasudevan, Abbas El Sahili, Julien Lescar   +8 more
openalex   +2 more sources

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Developing Allosteric Inhibitors of SARS-CoV-2 RNA-Dependent RNA Polymerase. [PDF]

ChemMedChem
Chayka A, Danda M, Dostálková A, Spiwok V, Klimešová A, Kapisheva M, Zgarbová M, Weber J, Ruml T, Rumlová M, Janeba Z.   +10 more
europepmc   +1 more source

A closely related group of RNA-dependent RNA polymerases from double-stranded RNA viruses

, 1993
Jeremy A. Bruenn
openalex   +2 more sources

Evaluating the Antiviral Efficacy of Encapsulated PKC Inhibitor BIM‐I against influenza A Virus Infection

Advanced Healthcare Materials, EarlyView.
This study explores nanoparticle delivery of the protein kinase C inhibitor bisindolylmaleimide‐I (BIM‐I) to combat influenza A virus infections. Encapsulation in biodegradable PLGA nanoparticles improved safety while maintaining the compound's strong antiviral activity.
Laura Klement, Jana Ismail, Josefine Schroeder, Amod Godbole, Johanna Schreiber, Christine Weber, Zoltan Cseresnyes, Marc T. Figge, Bettina Löffler, Ulrich S. Schubert, Stephanie Schubert, Christina Ehrhardt, Carsten Hoffmann   +12 more
wiley   +1 more source

Construction and validation of a cell based reporter assay for identifying inhibitors of SARS coronavirus 2 RNA dependent RNA polymerase activity. [PDF]

Sci Rep
Kang E, Yoon H, Lee J, Lee J, Kim S, Jo I, Han SB, Jeong DG, Cho S.   +8 more
europepmc   +1 more source

Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

, 2012
Jamie J. Arnold, Suresh D. Sharma, Joy Y. Feng, Adrian S. Ray, Eric D. Smidansky, Maria L. Kireeva, Aesop Cho, Jason K. Perry, Jennifer E. Vela, Yeojin Park, Yili Xu, Tian Yang, Darius Babusis, Ona Barauskus, Blake R. Peterson, Averell Gnatt, Mikhail Kashlev, Weidong Zhong, Craig E. Cameron   +18 more
openalex   +2 more sources