Results 231 to 240 of about 806,296 (336)

Potential RNA-dependent RNA polymerase (RdRp) inhibitors as prospective drug candidates for SARS-CoV-2. [PDF]

Eur J Med Chem, 2023
Bekheit MS, Panda SS, Girgis AS.
europepmc   +1 more source

Binding and transcription of simian virus 40 DNA by DNA-dependent RNA polymerase from Escherichia coli [PDF]

, 1978
P Hale, Jacob Lebowitz
openalex   +1 more source

SIRT3‐Mediated Deacetylation of DRP1K711 Prevents Mitochondrial Dysfunction in Parkinson's Disease

Advanced Science, EarlyView.
SIRT3‐mediated deacetylation of DRP1 at K711 resists mitochondrial dysfunction and DA neuronal death in PD, uncovering a treatment target. Abstract Dysregulation of mitochondrial dynamics is a key contributor to the pathogenesis of Parkinson's disease (PD).
Ye Xi, Kai Tao, Xiaomin Wen, Dayun Feng, Zifan Mai, Hui Ding, Honghui Mao, Mingming Wang, Qian Yang, Jie Xiang, Jie Zhang, Shengxi Wu   +11 more
wiley   +1 more source

Sofosbuvir: A Potential Treatment for Ebola

Frontiers in Pharmacology, 2018
Sandra E. Reznik, Sandra E. Reznik, Amit K. Tiwari, Charles R. Ashby   +3 more
doaj   +1 more source

TRIM56 restricts Coxsackievirus B infection by mediating the ubiquitination of viral RNA-dependent RNA polymerase 3D. [PDF]

PLoS Pathog
Wang Y, Dong Y, Luan T, Chen Y, Lin L, Li S, Feng D, Wei J, Fei Y, Wang G, Pan J, Wang Y, Zhong Z, Zhao W.   +13 more
europepmc   +1 more source

De Novo Potent Peptide Nucleic Acid Antisense Oligomer Inhibitors Targeting SARS-CoV-2 RNA-Dependent RNA Polymerase via Structure-Guided Drug Design. [PDF]

Int J Mol Sci, 2023
Shehzadi K, Yu M, Liang J.
europepmc   +1 more source

Modification of human DNA-dependent RNA polymerase activity by cyclic GMP [PDF]

, 1977
Leslie D. Johnson, John W. Hadden
openalex   +1 more source

Caspase‐6/Gasdermin C‐Mediated Tumor Cell Pyroptosis Promotes Colorectal Cancer Progression Through CXCL2‐Dependent Recruitment of Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
Hypoxic and low‐glucose conditions in tumor tissues trigger colorectal tumor cell pyroptosis via sequential activation of the Caspase‐1/Caspase‐6/GSDMC axis. High mobility group box 1 (HMGB1), released from GSDMC‐mediated pyroptotic tumor cells, upregulates CXCL2 expression in adjacent tumor cells, thereby recruiting myeloid‐derived suppressor cells ...
Hanchao Gao, Yikun Yao, Weilong Li, Zigan Xu, Wenjun Hu, Kewang Luo, Peishan Chen, Wanjing Shang, Shaodong Luan, Guojun Shi, Mengtao Cao, Pengfei Chen   +11 more
wiley   +1 more source

Identification of novel inhibitors of dengue viral NS5 RNA-dependent RNA polymerase through molecular docking, biological activity evaluation and molecular dynamics simulations. [PDF]

J Enzyme Inhib Med Chem
Zong K, Wei C, Li W, Wang C, Ruan J, Liu X, Zhang S, Yan H, Cao R, Li X.   +9 more
europepmc   +1 more source