Results 261 to 270 of about 509,868 (288)

Cy-1, a major QTL for tomato leaf curl New Delhi virus resistance, harbors a gene encoding a DFDGD-Class RNA-dependent RNA polymerase in cucumber (Cucumis sativus). [PDF]

BMC Plant Biol
Koeda S, Yamamoto C, Yamamoto H, Fujishiro K, Mori R, Okamoto M, Nagano AJ, Mashiko T.   +7 more
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Discovery and In Silico Characterization of a Novel Small Molecule Inhibitor Targeting Rabies Virus RNA-Dependent RNA Polymerase (RdRp)

Mohammed Kassab
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RNA Editing with Viral RNA-Dependent RNA Polymerase

ACS Synthetic Biology, 2022
RNA editing is currently attracting attention as a method for editing genetic information without injury to the genome. The most common approach to edit RNA sequences involves the induction of an A-to-I change by adenosine deaminase acting on RNA (ADAR). However, this method only allows point editing.
Shinzi Ogasawara, Ai Yamada
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Picornavirus RNA-dependent RNA polymerase

The International Journal of Biochemistry & Cell Biology, 2009
Replication of the picornavirus genome is catalysed by a viral encoded RNA-dependent RNA polymerase, termed 3D polymerase. Together with other viral and host proteins, this enzyme performs its functions in the cytoplasm of host cells. The crystal structure of 3D polymerase from a number of picornaviruses has been determined.
Chee Choy, Kok, Peter C, McMinn
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RNA-dependent RNA polymerases in RNA silencing

Biological Chemistry, 2011
Abstract RNA-dependent RNA polymerases (RdRPs) synthesize double-stranded RNAs that are processed into small RNAs and mediate gene silencing. Viral RdRPs and cellular RdRPs show little structural homology to each other. Cellular RdRPs play key roles in RNA silencing by producing complementary strands for target RNAs via Dicer-dependent and -
Yoshiko, Maida, Kenkichi, Masutomi
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RNA-dependent RNA polymerases from Flaviviridae

Current Opinion in Structural Biology, 2009
Viral genome replication in Flaviviridae is carried out by a virally encoded RNA-dependent RNA polymerase (RdRp). These viruses initiate the RNA synthesis via a de novo mechanism that differs from the primer-dependent mechanism used by Picornaviridae. Like all polymerases, the structure of Flaviviridae RdRps resembles a right hand with characteristic ...
Kyung H, Choi, Michael G, Rossmann
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RNA‐Dependent DNA Polymerases

Current Protocols in Molecular Biology, 2008
AbstractReverse transcriptases (RTs) are multifunctional enzymes, but are mainly used as RNA‐directed DNA polymerases in first‐strand cDNA synthesis. Specifically, oligodeoxynucleotides are used as primers for extension on RNA templates. The DNA synthesized from an RNA template is referred to as complementary DNA (cDNA) and is often used as a template ...
George, Tzertzinis, Stanley, Tabor, Nicole M, Nichols   +2 more
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RNA-dependent RNA polymerase in Chinese cabbage

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract An RNA-dependent RNA polymerase which incorporates nucleotides from ribonucleoside triphosphates into an acid-insoluble polymer has been purified from the chloroplastic fraction of Chinese cabbage leaves. 1. 1. Addition of RNA template is required for enzymatic activity; the synthetic polynucleotide poly (U, C) and TYMV-RNA are among the
S, Astier-Manifacier, P, Cornuet
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RNA-Dependent RNA Polymerases, Viruses, and RNA Silencing

Science, 2002
Most viruses have RNA genomes that are replicated and transcribed into messenger RNA by viral RNA–dependent RNA polymerases (RdRps), usually in concert with other viral and host factors. Many, if not most, eukaryotes also encode putative RdRps that have been implicated in sequence-specific, RNA-triggered gene silencing.
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Hepatitis C Virus RNA-Dependent RNA Polymerase (NS5B Polymerase)

2000
Approximately 170 million people world-wide are chronically infected with the hepatitis C virus (HCV) (BRADLEY et al. 1983; CHOO et al. 1989; HOUGHTON 1996; A;LTER 1997; also see Thomas, this volume). Although chronic infection with HCV frequently produces no symptoms for 5–30 years, it eventually has adverse effects on the host and constitutes a major
C H, Hagedorn, E H, van Beers, C, De Staercke   +2 more
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