Results 71 to 80 of about 806,296 (336)

Growth-rate dependent partitioning of RNA polymerases in bacteria [PDF]

Proc. Natl. Acad. Sci. USA 105, 20245-20250 (2008), 2008
Physiological changes which result in changes in bacterial gene expression are often accompanied by changes in the growth rate for fast adapting enteric bacteria. Since the availability of RNA polymerase (RNAP) in cells is dependent on the growth rate, transcriptional control involves not only the regulation of promoters, but also depends on the ...
arxiv   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Global phylogenetic analysis of the RNA-dependent RNA polymerase with OrViT (OrthornaVirae Tree)

Frontiers in Virology, 2022
Viruses of the kingdom Orthornavirae are the causative agents of many diseases in humans, animals and plants and play an important role in the ecology of the biosphere.
Dong-Qiang Cheng, Sandra Kolundžija, Federico M. Lauro, Federico M. Lauro   +3 more
doaj   +1 more source

A Magnetic Tweezers Study of a RNA-Dependant RNA Polymerase [PDF]

Biophysical Journal, 2012
RNA-dependent RNA Polymerases (RdRPs) are involved in the transcription and the replication of RNA genome of many viruses. The RdRP of the bacteriophage Φ6 (P2) is located inside the viral capsid where it transcribes double-stranded RNA to yield single-stranded RNA that infects the host cytosol.Here, we have studied the transcription activity of the P2
Minna M. Poranen, Martin Depken, David Dulin, Igor D. Vilfan, Susanne Hage, Wiecher Kamping, Dennis H. Bamford, Nynke H. Dekker   +7 more
openaire   +2 more sources

SARS-CoV-2 and miRNA-like inhibition power [PDF]

arXiv, 2020
(1) Background: RNA viruses and especially coronaviruses could act inside host cells not only by building their own proteins, but also by perturbing the cell metabolism. We show the possibility of miRNA-like inhibitions by the SARS-CoV-2 concerning for example the hemoglobin and type I interferons syntheses, hence highly perturbing oxygen distribution ...
arxiv  

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

Viruses, 2019
Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug that shows broad-spectrum antiviral activity against several RNA viruses.
Egor P. Tchesnokov, Joy Y. Feng, Danielle P. Porter, Matthias Götte   +3 more
doaj   +1 more source

Computationally repurposed drugs and natural products against RNA dependent RNA polymerase as potential COVID-19 therapies

Molecular Biomedicine, 2021
Repurposing of existing drugs and drug candidates is an ideal approach to identify new potential therapies for SARS-CoV-2 that can be tested without delay in human trials of infected patients.
Sakshi Piplani, Puneet Kumar Singh, David A. Winkler, Nikolai Petrovsky   +3 more
doaj   +1 more source

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

Molecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina, Viviana Bazan, Nadia Barraco, Simona Taverna, Mauro Manno, Samuele Raccosta, Anna Paola Carreca, Marco Bono, Tancredi Didier Bazan Russo, Francesco Pepe, Pasquale Pisapia, Lorena Incorvaia, Giuseppe Badalamenti, Giancarlo Troncone, Umberto Malapelle, Daniele Santini, Antonio Russo, Antonio Galvano   +17 more
wiley   +1 more source

Glutathionylation of dengue and Zika NS5 proteins affects guanylyltransferase and RNA dependent RNA polymerase activities. [PDF]

PLoS ONE, 2018
It has been estimated for dengue infection that the global population at risk is 3.5 billion people, which makes dengue an important public health problem. The causative agents of dengue are dengue viruses.
Chonticha Saisawang, Atichat Kuadkitkan, Prasert Auewarakul, Duncan R Smith, Albert J Ketterman   +4 more
doaj   +1 more source