Results 331 to 340 of about 2,153,086 (396)

MUTE‐Seq: An Ultrasensitive Method for Detecting Low‐Frequency Mutations in cfDNA With Engineered Advanced‐Fidelity FnCas9

Advanced Materials, EarlyView.
An advanced‐fidelity CRISPR nuclease, FnCas9‐AF2, is rationally engineered to discriminate single‐base mismatches with unprecedented level precision. Integrated into the MUTE‐Seq workflow, FnCas9‐AF2 depletes wild‐type cell‐free DNA, thereby exposing rare tumor‐derived mutant DNA (a molecular “needle in a haystack”).
Sunghyeok Ye, Jin‐Soo Kim, Myungshin Kim, Ki‐Yeon Kim, Yoon‐Ho Won, Taegun Park, Sungjae An, Haerin Jeong, Hee‐Joon Chung, In Seon Lee, Myoung‐Hee Kang, Chan Young Kang, Mi Young Kim, Jae Ho Chung, Jeong‐An Gim, Woochang Hwang, Yonggoo Kim, Song Cheol Kim, Sungho Lee, Junho K Hur, Junseok W Hur   +20 more
wiley   +1 more source

Unveiling the prognostic significance of RNA editing-related genes in colon cancer: evidence from bioinformatics and experiment. [PDF]

Eur J Med Res
Deng Z, Jin X, Liu B, Zhen H, Wang X.
europepmc   +1 more source

Characterization of RNA editing and gene therapy with a compact CRISPR-Cas13 in the retina. [PDF]

Proc Natl Acad Sci U S A
Kumar S, Hsiao YW, Wong VHY, Aubin D, Wang JH, Lisowski L, Rakoczy EP, Li F, Alarcon-Martinez L, Gonzalez-Cordero A, Bui BV, Liu GS.   +11 more
europepmc   +1 more source

Global A-to-I RNA editing during myogenic differentiation of goat MuSCs. [PDF]

Front Vet Sci
Xu X, Zhang M, Zhan S, Chen Y, Wei C, Cao J, Guo J, Dai D, Wang L, Zhong T, Zhang H, Li L.   +11 more
europepmc   +1 more source

Identification of RNA Editing Sites Reveals Functional Modifications with the Addition of Methionine to the Daily Rations of Yaks. [PDF]

Animals (Basel)
Wu S, Liu X, Liu Y, Wang S, Peng W, Zhang M, Yue B, Wang H, Wang J, Zhong J, Sun F, Kangzhu Y, Wang J.   +12 more
europepmc   +1 more source

REDInet: a temporal convolutional network-based classifier for A-to-I RNA editing detection harnessing million known events. [PDF]

Brief Bioinform
Fonzino A, Mazzacuva PL, Handen A, Silvestris DA, Arnold A, Pecori R, Pesole G, Picardi E.   +7 more
europepmc   +1 more source

Structural perspectives on adenosine to inosine RNA editing by ADARs. [PDF]

Mol Ther Nucleic Acids
Fisher AJ, Beal PA.
europepmc   +1 more source