Results 91 to 100 of about 247,454 (281)
Interconnections between m 6 A RNA modification, RNA structure, and protein–RNA complex assembly
Life Science AllianceThis review summarizes current knowledge and future directions on the mechanisms that govern the interplay between m 6 A RNA modification, RNA folding, and protein–RNA interactions, focusing on the mechanisms and available quantitative information ...
Simone Höfler, Olivier Duss
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RNA G-quadruplex structures exist and function in vivo in plants
Genome Biology, 2020 Background Guanine-rich sequences are able to form complex RNA structures termed RNA G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are suggested to be associated with important biological ...
Xiaofei Yang +10 more
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RNA-RNA interaction prediction based on multiple sequence alignments
, 2010 Many computerized methods for RNA-RNA interaction structure prediction have been developed. Recently, $O(N^6)$ time and $O(N^4)$ space dynamic programming algorithms have become available that compute the partition function of RNA-RNA interaction ...
Li, Andrew X. +3 more
core +1 more source
A new procedure to analyze RNA non-branching structures [PDF]
, 2015 RNA structure prediction and structural motifs analysis are challenging tasks in the investigation of RNA function. We propose a novel procedure to detect structural motifs shared between two RNAs (a reference and a target).
FISCON, GIULIA +3 more
core +1 more source
Nucleic Acids Research, 1984 The folding of single-stranded RNA into its secondary structure is postulated to be equivalent to the simple rule that the next double-helical region (stem) to form is the one with the largest equilibrium constant. The rule is tested and shown to give results consistent with the enzyme cleavage data of several sequences.
openaire +3 more sources
Compact Intermediates in RNA Folding [PDF]
Annual Review of Biophysics, 2010 Large noncoding RNAs fold into their biologically functional structures via compact yet disordered intermediates, which couple the stable secondary structure of the RNA with the emerging tertiary fold. The specificity of the collapse transition, which coincides with the assembly of helical domains, depends on RNA sequence and counterions.
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, 2022 We study RNA foldings and investigate their topology using a combination of knot theory and embedded rigid vertex graphs. Knot theory has been helpful in modeling biomolecules, but classical knots place emphasis on a biomolecule's entanglement while ignoring their intrachain interactions.
Ceniceros, Jose +3 more
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Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Frnakenstein: multiple target inverse RNA folding
BMC Bioinformatics, 2012 Background RNA secondary structure prediction, or folding, is a classic problem in bioinformatics: given a sequence of nucleotides, the aim is to predict the base pairs formed in its three dimensional conformation.
Lyngsø Rune B +5 more
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source