Results 101 to 110 of about 844,014 (252)

RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells

, 2023
The availability of nucleotides has a direct impact on transcription. Inhibition of dihydroorate dehydrogenase (DHODH) with leflunomide impacts nucleotide pools by reducing pyrimidine levels.
Santoriello, Cristina, Adelman, Karen, Fazio, Maurizio, Superdock, Michael, Kalocsay, Marian, Dorjsuren, Bilguujin, Abraham, Brian, Jurynec, Michael, McCall, Wyatt, Flynn, Ryan, Stanhope, Meredith, Adatto, Isaac, Yang, Song, Sporrij, Audrey, Zhou, Yi, Calo, Elizier, Zon, Leonard, Custo Greig, Eugenia, Henqriques, Telmo   +18 more
core   +1 more source

Coupling between the DEAD-box RNA helicases Ded1p and eIF4A

eLife, 2016
Eukaryotic translation initiation involves two conserved DEAD-box RNA helicases, eIF4A and Ded1p. Here we show that S. cerevisiae eIF4A and Ded1p directly interact with each other and simultaneously with the scaffolding protein eIF4G.
Zhaofeng Gao, Andrea A Putnam, Heath A Bowers, Ulf-Peter Guenther, Xuan Ye, Audrey Kindsfather, Angela K Hilliker, Eckhard Jankowsky   +7 more
doaj   +1 more source

Mitochondria‐endoplasmic reticulum organelle glue as maturation promoter for origination/dimensional dual‐cross cardiomyocytes

BMEMat, EarlyView.
Mitochondria‐endoplasmic reticulum contact sites (MERCS) are areas where the mitochondria and endoplasmic reticulum closely interact. In this study, we utilize synthetic organelle glues to artificially engineer MERCS for regulating cardiomyocyte development, through which the immature and chemo‐plasticity issues of undifferentiated cells are addressed.
Wei Tang, Hao Sun, Chenqi Duan, Jiajia Chang, Yuxing Wang, Ming Zhao, Huiyue Zhao, Shan Lu, Yang Yang, Da Huo   +9 more
wiley   +1 more source

Conditional, temperature-induced proteolytic regulation of cyanobacterial RNA helicase expression [PDF]

, 2014
Conditional proteolysis is a crucial process regulating the abundance of key regulatory proteins associated with the cell cycle, differentiation pathways, or cellular response to abiotic stress in eukaryotic and prokaryotic organisms. We provide evidence
Chamot, Danuta, Tarassova, Oxana S., Owttrim, George W.   +2 more
core   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin

Chemistry – A European Journal, EarlyView.
The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You, Monica Ching Suen, Haitao Miao, Yanyan Geng, Rahman Ud Din, Mu Yuan, Qiang Xue, Xiaoting Li, Naining Xu, Zhihong Guo, Hon‐Ming Lam, Kwok‐Wai Lo, Changdong Liu, Guang Zhu   +13 more
wiley   +1 more source

RNA structural rearrangement via unwinding and annealing by the cyanobacterial RNA helicase, CrhR

, 2005
Rearrangement of RNA secondary structure is crucial for numerous biological processes. RNA helicases participate in these rearrangements through the unwinding of duplex RNA.
Chamot, Danuta, Colvin, Kimberley R., Owttrim, George W., Kujat-Choy, Sonya L.   +3 more
core   +1 more source

RNA-dependent association with myosin IIA promotes F-actin-guided trafficking of the ELAV-like protein HuR to polysomes [PDF]

, 2013
The role of the mRNA-binding protein human antigen R (HuR) in stabilization and translation of AU-rich elements (ARE) containing mRNAs is well established.
Eberhardt, Wolfgang, Schulz, Sebastian, Pfeilschifter, Josef, Doller, Anke   +3 more
core   +1 more source

AltMV TGB1 Nucleolar Localization Requires Homologous Interaction and Correlates with Cell Wall Localization Associated with Cell-to-Cell Movement

The Plant Pathology Journal, 2013
The Potexvirus Alternanthera mosaic virus (AltMV) has multifunctional triple gene block (TGB) proteins, among which our studies have focused on the properties of the TGB1 protein.
Jiryun Nam, Moon Nam, Hanhong Bae, Cheolho Lee, Bong-Chun Lee, John Hammond, Hyoun-Sub Lim   +6 more
doaj   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source