Results 271 to 280 of about 125,618 (325)

Transforming Growth Factor‐β Pathway: Biological Functions and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
Natural compounds modulate the TGF‐β pathway, which acts as both a tumor suppressor and promoter during cancer progression. Agents such as ginsenosides, halofuginone, and EGCG influence cell proliferation, apoptosis, and angiogenesis. These bioactive molecules may complement standard therapies, highlighting the need for advanced formulations ...
Reham Hassan Mekky, Mohammed E. Abo‐El Fetoh, Safaa A. Faheem, Abdullah F. Radwan, Mariam H. Fawzy, Aya M. Mustafa, Mohamed A. Said, Daniela Calina, Javad Sharifi‐Rad, William C. Cho   +9 more
wiley   +1 more source

RNA helicase SKIV2L limits antiviral defense and autoinflammation elicited by the OAS-RNase L pathway. [PDF]

EMBO J
Yang K, Dong B, Asthana A, Silverman RH, Yan N.   +4 more
europepmc   +1 more source

Synthesis and Chemical Characterization of Chloroquine, Hydroxychloroquine, Zinc, and Cinnamic Acid Organocomplexes: Potential Drug Candidates for SARS‐CoV‐2 Treatment and Microbial Control

ChemistrySelect, Volume 10, Issue 27, July 18, 2025.
Zn‐quinolines were synthesized with high yields of 78% and 85%. The study focuses on drug repositioning to improve properties and reduce toxicity for COVID‐19 treatment. New Zn‐based compounds demonstrated antiviral and antimicrobial activities with low toxicity.
Carla Peron, Paulo Roberto dos Santos, João Pedro de Oliveira Mezzomo, Fernando Joel Scariot, Ariel Maia, Laura Calle Gonzalez, Deise do Nascimento de Freitas, Ana Paula Longaray Delamare, Pablo Machado, Ana Paula Duarte de Souza, Sidnei Moura   +10 more
wiley   +1 more source

RNA helicase D1PAS1 resolves R-loops and forms a complex for mouse pachytene piRNA biogenesis required for male fertility. [PDF]

Nucleic Acids Res
Choi H, Zhou L, Zhao Y, Dean J.
europepmc   +1 more source

Formalin‐fixed paraffin‐embedded (FFPE) samples help to investigate transcriptomic responses in wildlife disease

Molecular Ecology Resources, Volume 25, Issue 5, July 2025.
Abstract Infectious diseases impact numerous organisms. Knowledge of host‐pathogen interactions and host responses to infection is crucial for conservation and management. Obtaining this knowledge quickly is made increasingly possible by a variety of genomic approaches, yet, for many species the bottleneck to understanding this, remains access to ...
Allison K. Miller, Cara L. Brosnahan, Anjali Pande, Cindy F. Baker, Jemma L. Geoghegan, Jane Kitson, Neil J. Gemmell, Edwina J. Dowle   +7 more
wiley   +1 more source

The RNA helicase DDX21 activates YAP to promote tumorigenesis and is transcriptionally upregulated by β-catenin in colorectal cancer. [PDF]

Oncogene
Tang W, Yang Y, Fu Z, Xu W, Ou W, Liu F, Du P, Liu CY.   +7 more
europepmc   +1 more source

An isothermal workflow for low‐cost and PCR‐free field‐based community metabarcoding

Methods in Ecology and Evolution, Volume 16, Issue 7, Page 1413-1424, July 2025.
Abstract DNA metabarcoding has revolutionized our ability to monitor ecosystems. However, the method is still rarely used in developing countries where resources are limited and fieldwork is challenging. To overcome this limitation, we designed a comprehensive workflow allowing rapid community metabarcoding with minimum, self‐manufacturable equipment ...
Amadeus Plewnia, Henrik Krehenwinkel, Christopher Heine   +2 more
wiley   +1 more source

DEAD-box RNA helicase RH20 positively regulates RNAi-based antiviral immunity in plants by associating with SGS3/RDR6 bodies. [PDF]

Plant Biotechnol J
Wen Z, Hu R, Pi Q, Zhang D, Duan J, Li Z, Li Q, Zhao X, Yang M, Zhao X, Liu D, Su Z, Li D, Zhang Y.   +13 more
europepmc   +1 more source

Insights Into Cockayne Syndrome Type B: What Underlies Its Pathogenesis?

Aging Cell, Volume 24, Issue 7, July 2025.
Cockayne Syndrome complementation group B (CS‐B) is a highly debilitating progeroid syndrome that often culminates in the death of patients before adulthood. This review explores the pathogenesis of CS‐B and proposes that a combination of DNA damage accumulation, transcriptional dysregulation, and mitochondrial dysfunction is its underlying cause ...
Ricardo Afonso‐Reis, Cristiana R. Madeira, David V. C. Brito, Clévio Nóbrega   +3 more
wiley   +1 more source

An RNA Helicase DHX33 Inhibitor Shows Broad Anticancer Activity via Inducing Ferroptosis in Cancer Cells. [PDF]

ACS Omega
Tang X, Deng Y, Liang Y, Liao D, Wen F, Zhang Y.   +5 more
europepmc   +1 more source