Results 261 to 270 of about 1,508,120 (294)
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2007
Silencing of gene expression by RNA interference (RNAi) has become a powerful tool for functional genomics in mammalian cells. Furthermore, RNAi holds promise as a simple, fast and cost-effective approach to studying mammalian gene function in vivo and as a novel therapeutic approach.
R, Kühn, S, Streif, W, Wurst
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Silencing of gene expression by RNA interference (RNAi) has become a powerful tool for functional genomics in mammalian cells. Furthermore, RNAi holds promise as a simple, fast and cost-effective approach to studying mammalian gene function in vivo and as a novel therapeutic approach.
R, Kühn, S, Streif, W, Wurst
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Branched RNA nanostructures for RNA interference
Chemical Communications, 2011Branched RNAs with three- or four-way junctions were designed by assembling single-stranded RNA for RNA interference. Human Dicer transformed branched RNAs into about 20 base pairs of double-stranded RNA, which is a standard siRNA species. Our tetramer design provides a potent silencing effect over a period of 5 days.
Yuko, Nakashima +4 more
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RNA Interference for the Treatment of Cancer
Drug News & Perspectives, 2006RNA interference (RNAi) is the latest new technology in the field of genetic medicine in which specific genes can be turned off, or silenced, so as to affect a therapeutic outcome. It can be highly specific, works in the nanomolar range and is far more effective than the antisense approaches popular 10-15 years ago. Here we review the field and explore
Putral, Lisa N. +2 more
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Lentiviral-Mediated RNA Interference
Human Gene Therapy, 2002RNA interference (RNAi) is a form of posttranscriptional gene silencing mediated by short double-stranded RNA, known as small interfering RNA (siRNA). These siRNAs are capable of binding to a specific mRNA sequence and causing its degradation. The recent demonstration of a plasmid vector that directs siRNA synthesis in mammalian cells prompted us to ...
Abbas-Terki, T. +4 more
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Antisense-RNA regulation and RNA interference
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002For a long time, RNA has been merely regarded as a molecule that can either function as a messenger (mRNA) or as part of the translational machinery (tRNA, rRNA). Meanwhile, it became clear that RNAs are versatile molecules that do not only play key roles in many important biological processes like splicing, editing, protein export and others, but can ...
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2007
Publisher Summary This chapter discusses the possible roles for RNA interference (RNAi) in the human immunodeficiency virus type 1 (HIV‐1) life cycle and the way in which HIV‐1 might use protein and RNA elements to regulate RNA‐based viral restriction. RNAi can regulate a variety of biological processes.
Le, S, Yeung, ML, Bennasser, Y, Jeang, K
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Publisher Summary This chapter discusses the possible roles for RNA interference (RNAi) in the human immunodeficiency virus type 1 (HIV‐1) life cycle and the way in which HIV‐1 might use protein and RNA elements to regulate RNA‐based viral restriction. RNAi can regulate a variety of biological processes.
Le, S, Yeung, ML, Bennasser, Y, Jeang, K
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RNA Interference: From Basic Research to Therapeutic Applications
Angewandte Chemie - International Edition, 2009Jens Kurreck
exaly
Proceedings of the National Academy of Sciences of the United States of America, 2011
John van der Oost +2 more
exaly
John van der Oost +2 more
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