Results 101 to 110 of about 1,353,045 (362)

The novel E3 ligase of PPAR?? TRIM25 regulates adipocyte differentiation [PDF]

, 2018
Department of Biological SciencesPeroxisome proliferator-activated receptor ?? (PPAR??) is a ligand-dependent transcription factor which regulates glucose homeostasis and adipocyte differentiation.
Lee, Jae Min
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma

Cell Death Discovery, 2023
CDK12 is a transcriptional cyclin-dependent kinase (CDK) that interacts with cyclin K to regulate different aspects of gene expression. The CDK12-cyclin K complex phosphorylates several substrates, including RNA polymerase II (Pol II), and thereby ...
Thibault Houles, Jonathan Boucher, Geneviève Lavoie, Graham MacLeod, Sichun Lin, Stephane Angers, Philippe P. Roux   +6 more
doaj   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Novel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1.

PLoS Neglected Tropical Diseases, 2010
BackgroundNeglected tropical diseases, including diseases caused by trypanosomatid parasites such as Trypanosoma brucei, cost tens of millions of disability-adjusted life-years annually.
Jacob D Durrant, Laurence Hall, Robert V Swift, Melissa Landon, Achim Schnaufer, Rommie E Amaro   +5 more
doaj   +1 more source

Is the Trypanosoma brucei REL1 RNA Ligase Specific for U-deletion RNA Editing, and Is the REL2 RNA Ligase Specific for U-insertion Editing? [PDF]

Journal of Biological Chemistry, 2003
It was shown previously that the REL1 mitochondrial RNA ligase in Trypanosoma brucei was a vital gene and disruption affected RNA editing in vivo, whereas the REL2 RNA ligase gene could be down-regulated with no effect on cell growth or on RNA editing. We performed down-regulation of REL1 in procyclic T. brucei (midgut insect forms) by RNA interference
Larry Simpson, Larry Simpson, Guanghan Gao   +2 more
openaire   +3 more sources

Matrix: a complex amalgam of structures and functions in tumor microenvironment

FEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis, Evgenia Tsoukala, Theodora D. Sarantopoulou, Maria‐Elpida Christopoulou   +3 more
wiley   +1 more source

Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner

Cell Reports, 2023
Summary: Type I interferon (IFN-I) signaling is central to inducing antiviral innate immunity. However, the mechanisms for IFN-I signaling self-regulation are still largely unknown.
Xianghui Kong, Xinliang Lu, Shibo Wang, Jiayue Hao, Danfeng Guo, Hao Wu, Yu Jiang, Yi Sun, Jianli Wang, Gensheng Zhang, Zhijian Cai   +10 more
doaj  

Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity [PDF]

, 2017
MDM2–MDMX complexes bind the p53 tumor-suppressor protein, inhibiting p53's transcriptional activity and targeting p53 for proteasomal degradation. Inhibitors that disrupt binding between p53 and MDM2 efficiently activate a p53 response, but their use in
A Plechanovová, A Plechanovová, Andreas K Hock, CS Chen, D Migliorini, D Shi, Danny T Huang, DC Scott, DE Christensen, Dominika Kowalczyk, E Branigan, E Meulmeester, Gary J Sibbet, H Dou, H Dou, H Kawai, H Kawai, I Ray-Coquard, J Momand, J Parant, JC Badciong, JD Oliner, JG Sanchez, JN Pruneda, K Itahana, K Linke, Karen H Vousden, KH Khoo, Koji Nomura, L Buetow, L Buetow, L Huang, LA Tollini, LC Storoni, LK Linares, LT Vassilev, M Andreeff, M Argentini, M Bista, M Kostic, Marta Klejnot, MG Koliopoulos, MHG Kubbutat, ML Choong, MS Dai, MS Dai, MV Poyurovsky, MW Jackson, N Minsky, N Zheng, P Dolezelova, P Emsley, P Roxburgh, PD Adams, PS Brzovic, Q Cheng, Q Cheng, Q Ding, R Honda, R Montes de Oca Luna, R Stad, R Stad, RA Finch, RK Geyer, S Iyappan, S Shangary, S Uldrijan, SN Jones, UM Moll, V Pant, W Kabsch, Y Pan   +71 more
core   +1 more source

Structural bias in T4 RNA ligase-mediated 3′-adapter ligation

Nucleic Acids Research, 2012
T4 RNA ligases are commonly used to attach adapters to RNAs, but large differences in ligation efficiency make detection and quantitation problematic.
Fanglei Zhuang, Ryan T. Fuchs, Zhiyi Sun, Yu Zheng, G. B. Robb   +4 more
semanticscholar   +1 more source