Results 131 to 140 of about 1,338,157 (346)

Prediction of RNA pseudoknots by Monte Carlo simulations [PDF]

arXiv, 2004
In this paper we consider the problem of RNA folding with pseudoknots. We use a graphical representation in which the secondary structures are described by planar diagrams. Pseudoknots are identified as non-planar diagrams. We analyze the non-planar topologies of RNA structures and propose a classification of RNA pseudoknots according to the minimal ...
arxiv  

The novel E3 ligase of PPAR?? TRIM25 regulates adipocyte differentiation [PDF]

, 2018
Department of Biological SciencesPeroxisome proliferator-activated receptor ?? (PPAR??) is a ligand-dependent transcription factor which regulates glucose homeostasis and adipocyte differentiation.
Lee, Jae Min
core  

A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination [PDF]

, 2010
RNA crystallization and phasing represent major bottlenecks in RNA structure determination. Seeking to exploit antibody fragments as RNA crystallization chaperones, we have used an arginine-enriched synthetic Fab library displayed on phage to obtain Fabs
A Desmyter, A Ke, A Serganov, AA Kossiakoff, AC Messias, AL Edwards, Anthony A Kossiakoff, AR Ferré-D'Amaré, AR Ferré-D'Amaré, AY Keel, BL Golden, BM Lunde, BS Saville, C Eigenbrot, C Höbartner, C Keryer-Bibens, CG Hoogstraten, D Piekna-Przybylska, David M Shechner, David P Bartel, DM Shechner, EA Kabat, EH Ekland, Erica M Duguid, FA Fellouse, FA Fellouse, FA Fellouse, IA Laird-Offringa, J-D Ye, JA Chao, JA Doudna, Jingdong Ye, Joseph A Piccirilli, JR Hogg, JR Hogg, JS Mattick, JS Mattick, K Decanniere, M Jinek, MJ Fedor, MP Robertson, N Carrasco, NH Bergman, Nikolai B Suslov, P Kapranov, PJ Carter, R Dutzler, RJ Taft, RK Montange, S Birtalan, S Iwata, S Jones, S Koide, S Koide, S Uysal, Sachdev S Sidhu, SC Bagby, Shohei Koide, SL Reichow, SR Eddy, SS Sidhu, TA Cooper, V Tereshko, Yelena Koldobskaya   +63 more
core   +2 more sources

An RNA Ligase Essential for RNA Editing and Survival of the Bloodstream Form of Trypanosoma brucei

Science, 2001
RNA editing in trypanosomes occurs by a series of enzymatic steps that are catalyzed by a macromolecular complex. The TbMP52 protein is shown to be a component of this complex, to have RNA ligase activity, and to be one of two adenylatable proteins in ...
A. Schnaufer, A. Panigrahi, B. Panicucci, R. Igo, R. Salavati, K. Stuart   +5 more
semanticscholar   +1 more source

CXCL13 Damages Blood Spinal Cord Barrier by Promoting RNF6/Sqstm1‐Ubiquitination Induced Autophagy in Experimental Allergic Encephalomyelitis

Advanced Science, EarlyView.
In multiple sclerosis, the disruption of the blood‐spinal cord barrier (BSCB) induced by CXCL13 facilitates the infiltration of inflammatory cells into the central nervous system, resulting in demyelination and neuronal injury. Mechanistically, the deleterious impact of CXCL13 on the BSCB is associated with a reduction in tight junction protein ...
Jingjing Han, Rui Hong, Cong Cao, Wanhua Feng, Wei Zhuang, Gui Wang, Jingchao Tang, Ya Yang, Chu Zhang, Aihua Zhou, Xuebin Qu   +10 more
wiley   +1 more source

RNA sampling and crystallographic refinement using Rappertk [PDF]

arXiv, 2007
Background. Dramatic increases in RNA structural data have made it possible to recognize its conformational preferences much better than a decade ago. This has created an opportunity to use discrete restraint-based conformational sampling for modelling RNA and automating its crystallographic refinement. Results.
arxiv  

Exclusive neuronal expression of SUCLA2 in the human brain [PDF]

, 2013
SUCLA2 encodes the ATP-forming subunit (A-SUCL-) of succinyl-CoA ligase, an enzyme of the citric acid cycle. Mutations in SUCLA2 lead to a mitochondrial disorder manifesting as encephalomyopathy with dystonia, deafness and lesions in the basal ganglia ...
A Kowluru, A Minelli, A Navarro-Sastre, A Rotig, A Vozza, AA Gerencser, AC Yu, Aniko Gál, Arpád Dobolyi, Attila G. Bagó, B Przybyla-Zawislak, C Chinopoulos, C Chinopoulos, C Chinopoulos, C Chinopoulos, C Chinopoulos, C Miller, Christos Chinopoulos, DO Lambeth, E Brekke, E Ostergaard, E Ostergaard, E Ostergaard, E Ostergaard, E Pfaff, EE McKee, EE McKee, EF Kadrmas, Elsebet Ostergaard, F Conti, F Conti, G Kiss, JC Wallace, JD Johnson, JH Ottaway, L Milon, M Lopes-Cardozo, M Palkovits, M Thomson, Miklós Palkovits, ML Pall, Mária J. Molnár, N Westergaard, O Elpeleg, R Carrozzo, R Dringen, RF Labbe, RL Strausberg, RP Shank, S Tanner, Tamás Dóczi, TM Jenkins, U Sonnewald, Vera Adam-Vizi, X Li, Z Zhang   +55 more
core   +2 more sources

MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read‐Through Transcription, and Intragenic Contacts

Advanced Science, EarlyView.
MYC is a transcription factor (TF) that binds DNA near transcriptional start sites (TSSs) and within enhancer elements. Here, unappreciated sites of MYC binding in the vicinity of transcriptional end sites (TESs) of many genes in multiple cell types in association with numerous other TFs are described previously.
Huabo Wang, Bingwei Ma, Taylor Stevens, Jessica Knapp, Jie Lu, Edward V. Prochownik   +5 more
wiley   +1 more source

An observation of circular RNAs in bacterial RNA-seq data [PDF]

arXiv, 2016
Circular RNAs (circRNAs) are a class of RNA with an important role in micro RNA (miRNA) regulation recently discovered in Human and various other eukaryotes as well as in archaea. Here, we have analyzed RNA-seq data obtained from {\it Enterococcus faecalis} and {\it Escherichia coli} in a way similar to previous studies performed on eukaryotes.
arxiv  

Mapping the 5' and 3' ends of Tetrahymena thermophila mRNAs using RNA ligase mediated amplification of cDNA ends (RLM-RACE).

Nucleic Acids Research, 1993
A procedure is described for mapping the ends of RNAs. Using T4 RNA ligase, a DNA (3' end) or RNA (5' end) oligonucleotide is ligated to RNA ends followed by cDNA synthesis, PCR amplification, cloning and sequencing.
Xiuwen Liu, M. Gorovsky
semanticscholar   +1 more source