Results 151 to 160 of about 1,281,894 (266)

Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis

Advanced Science, EarlyView.
Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu, Chen Su, Jianling Liu, Mingyan Xing, Xiaoxia Wu, Lingxia Wang, Xiaoming Zhao, Hanwen Zhang, YangYang Xie, YangYang Wang, Hong Li, Yu Li, Ming Li, Haibing Zhang   +13 more
wiley   +1 more source

Structure and Mechanism of RNA Ligase

, 2004
C. Kiong Ho, Li‐Kai Wang, Christopher D. Lima, Stewart Shuman   +3 more
openalex   +1 more source

GLUL Confers Perivascular Cancer‐Associated Fibroblasts With Pro‐Angiogenic Capacity to Promote Glioma Progression

Advanced Science, EarlyView.
Schematic illustration of the proposed model. Primary CAFs are isolated from fresh human GBM specimens according to established protocols. GLUL is essential for pro‐angiogenic capacity of CAFs through its impact on the PI3K/AKT pathway. GLUL enhances the pro‐angiogenic capacity of CAFs, driving aberrant tumor vasculature that fuels tumor growth ...
Qing Zhang, Yida Liu, Zhi Zhang, Yang Wang, Fusheng Liu   +4 more
wiley   +1 more source

Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation. [PDF]

Proc Natl Acad Sci U S A
Hu Y, Lopez VA, Xu H, Pfister JP, Song B, Servage KA, Sakurai M, Jones BT, Mendell JT, Wang T, Wu J, Lambowitz AM, Tomchick DR, Pawłowski K, Tagliabracci VS.   +14 more
europepmc   +1 more source

Long Non-Coding RNA Nuclear-Enriched Abundant Transcript 1 (<i>NEAT1</i>) Facilitates Foam Cell Formation and Atherosclerosis Progression Through the miR-17-5p/Itchy E3 Ubiquitin Protein Ligase (ITCH)/Liver Kinase B1 (LKB1) Axis

Haifen Huang, Bin Peng, Qingyong Chen, Yi Wang, Li Ren   +4 more
openalex   +2 more sources

Author response: The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition

, 2020
Michael Zavortink, Lauren N. Rutt, Svetlana Dzitoyeva, Jesslyn C. Henriksen, Chloe Barrington, Danielle Y. Bilodeau, Miranda Wang, Xiao Xiao Chen, Olivia S. Rissland   +8 more
openalex   +1 more source

A chloroplastic RNA ligase activity analogous to the bacterial and archaeal 2´–5′ RNA ligase [PDF]

, 2012
Diego Molina‐Serrano, Jorge Sales Marques, María A. Nohales, Ricardo Flores, José‐Antonio Daròs   +4 more
openalex   +1 more source

A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB.

Molecules and Cells, 2014
Yanyan Lu, F. Liang, Xiaozhong Wang
semanticscholar   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

Evolution of the substrate specificity of an RNA ligase ribozyme from phosphorimidazole to triphosphate activation. [PDF]

Proc Natl Acad Sci U S A
DasGupta S, Weiss Z, Nisler C, Szostak JW.   +3 more
europepmc   +1 more source