Results 161 to 170 of about 1,281,894 (266)

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

RTP801 interacts with the tRNA ligase complex and dysregulates its RNA ligase activity in Alzheimer's disease. [PDF]

Nucleic Acids Res
Campoy-Campos G, Solana-Balaguer J, Guisado-Corcoll A, Chicote-González A, Garcia-Segura P, Pérez-Sisqués L, Torres AG, Canal M, Molina-Porcel L, Fernández-Irigoyen J, Santamaria E, Ribas de Pouplana L, Alberch J, Martí E, Giralt A, Pérez-Navarro E, Malagelada C.   +16 more
europepmc   +1 more source

A human RNA ligase that operates via auto- and RNA-AMPylation

, 2022
Yuan Y, Stumpf FM, Schlor LA, Schmidt OP, Huber LB, Frese M, Höllmüller E, Scheffner M, Stengel F, Diederichs K, Marx A.   +10 more
europepmc   +1 more source

Turnover of RNA-binding Proteins and MicroRNAs by intrinsically disordered region-directed ZSWIM8 ubiquitin ligase during brain development [PDF]

Jing Lei, Siming Zhong, Rong Fan, Xin Shu, Guan Wang, Jiansheng Guo, Shuting Xue, Luqian Zheng, Aiming Ren, Junfang Ji, Bing Yang, Shumin Duan, Zhiping Wang, Xing Guo   +13 more
openalex   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

Characterisation and engineering of a thermophilic RNA ligase from Palaeococcus pacificus. [PDF]

Nucleic Acids Res
Rousseau M, Oulavallickal T, Williamson A, Arcus V, Patrick WM, Hicks J.   +5 more
europepmc   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, EarlyView.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

RNA ligase reaction products in plasmolyzed Escherichia coli cells infected by T4 bacteriophage.

, 1979
Michael David, R Vekstein, Gabriel Kaufmann   +2 more
openalex   +2 more sources

Circularization of linear viroid RNA via 2′-phosphomonoester, 3′, 5′-phosphodiester bonds by a novel type of RNA ligase from wheat germ andChlamydomonas [PDF]

, 1982
Yo Kikuchi, Kazimierz Tyc, Witold Filipowicz, Heinz L. Sänger, Hans Groß   +4 more
openalex   +1 more source

Structures of the noncanonical RNA ligase RtcB reveal the mechanism of histidine guanylylation.

Biochemistry, 2013
Kevin K. Desai, C. Bingman, G. Phillips, Ronald T. Raines   +3 more
semanticscholar   +1 more source