Results 161 to 170 of about 1,338,157 (346)

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

BMC Biology, 2017
Background TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM) family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response.
Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski   +10 more
doaj   +1 more source

Reconstruction of tRNA^Phe molecules from the fragments by linkage with T‐4 RNA ligase in double‐stranded regions [PDF]

, 1984
A.S. Boutorin, Stanislav Vassilenko, Michail M. Baklanov, Yu. S. Nechaev   +3 more
openalex   +1 more source

COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
COPS5, which is overexpressed in HCC in an amplification‐ and ATF4‐dependent manner, stabilizes MK2 through deubiquitination and, in turn, induces HSPB1 activation, protecting HCC cells from ferroptosis and thus promoting sorafenib resistance and tumor progression. Abstract Sorafenib, which is proven to serve as a potent ferroptosis inducer, is used as
Ai‐Ling Luo, Wen‐Ying Zheng, Qiong Zhang, Yan Yuan, Mei‐Qi Li, Kai Du, An‐Ran Gao, Li‐Jun Pei, Jie Xie, Wen‐Hao Chen, Long Zhang, Xiu‐Zhu Guo, Xiao‐Ran Yang, Chao Zeng, Guo‐Hua Yang, Min Deng   +15 more
wiley   +1 more source

Fluorescence-, isotope- or biotin-labeling of the 5'-end of single-stranded DNA/RNA using T4 RNA ligase [PDF]

, 1997
Yohei Kinoshita, Koichi Nishigaki, Yuzuru Husimi   +2 more
openalex   +1 more source

Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination

Advanced Science, EarlyView.
Cardiomyocyte‐enriched USP20 regulates the K63‐linked ubiquitination of STAT3, and the cardiomyocyte‐specific USP20‐STAT3‐CARM1 axis exerts a protective role in cardiac hypertrophy. Targeting USP20 through cardiac‐specific gene therapy presents a promising strategy for the treatment of cardiac hypertrophy.
Lingfeng Zhong, Shanshan Dai, Fan Yu, Guo‐Ping Shi, Qinyan Gong, Yucong Zhang, Jingsi Duan, Zhengyin Lou, Zhixuan Tang, Fuzhe Gong, Derong Chen, Liya Hou, Xinyang Hu, Jinghai Chen, Jian'an Wang, Deling Yin   +15 more
wiley   +1 more source

circEPB41L2 blocks the progression and metastasis in non-small cell lung cancer by promoting TRIP12-triggered PTBP1 ubiquitylation

Cell Death Discovery
The metastasis of non-small cell lung cancer (NSCLC) is the leading death cause of NSCLC patients, which requires new biomarkers for precise diagnosis and treatment.
Yan Wang, Yihao Wang, Chunjie Wu, Yunfei Ji, Pingfu Hou, Xueqing Wu, Zhongwei Li, Minle Li, Sufang Chu, Qianqian Ning, Bo Xu, Junnian Zheng, Jin Bai   +12 more
doaj   +1 more source

How Large is the Universe of RNA-Like Motifs? A Clustering Analysis of RNA Graph Motifs Using Topological Descriptors [PDF]

arXiv
We introduce a computational topology-based approach with unsupervised machine-learning algorithms to estimate the database size and content of RNA-like graph topologies. Specifically, we apply graph theory enumeration to generate all 110,667 possible 2D dual graphs for vertex numbers ranging from 2 to 9.
arxiv  

Identification of candidate mitochondrial RNA editing ligases from Trypanosoma brucei [PDF]

, 2001
Michael T. McManus, Masako Shimamura, Jayleen Grams, Stephen L. Hajduk   +3 more
openalex   +1 more source

Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation

Advanced Science, EarlyView.
Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu, Tong Ji, Zhichao Ye, Jianing Yan, Chao Wang, Jiachen Chen, Ziyang Jin, Yongji Zhu, Xiujun Cai, Yifan Wang   +9 more
wiley   +1 more source

Nuclear‐Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance

Advanced Science, EarlyView.
Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu, Jiaqian Feng, Tingting Pan, Pinggen Zhang, Ling Ye, Zetan Jiang, Zilong Zhou, Qiankun Mao, Jian Li, Xinyi Yang, Ping Gao, De Huang, Huafeng Zhang   +12 more
wiley   +1 more source