Results 171 to 180 of about 1,338,157 (346)

Enzymatic Conjugation of Modified RNA Fragments by Ancestral RNA Ligase AncT4_2. [PDF]

Appl Environ Microbiol, 2022
Kajimoto S, Ohashi M, Hagiwara Y, Takahashi D, Mihara Y, Motoyama T, Ito S, Nakano S.   +7 more
europepmc   +1 more source

In vitro Evolution and Engineering for Improved Ribozyme Polymerase Production [PDF]

, 2011
According to the "RNA World Hypothesis" the first self replicating molecule formed from the prebiotic chemicals is the ribozyme. A model compartmentalized self replicating system for ribozyme polymerases is designed and used to improve activity,
Ayaz Ali Khan, Israr Khan, Muhammad Waheed Akktar   +2 more
core   +1 more source

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
wiley   +1 more source

Structures of RNA ligase RtcB in complexes with divalent cations and GTP. [PDF]

RNA, 2022
Jacewicz A, Dantuluri S, Shuman S.
europepmc   +1 more source

Metal Ion Requirements for Structure and Catalysis of an RNA Ligase Ribozyme [PDF]

, 2002
Margaret E. Glasner, Nicholas H. Bergman, David P. Bartel   +2 more
openalex   +1 more source

METTL14‐Induced M6A Methylation Increases G6pc Biosynthesis, Hepatic Glucose Production and Metabolic Disorders in Obesity

Advanced Science, EarlyView.
It is shown that obesity is associated with increases in hepatic METTL14 and m6A methylation of G6pc transcript. YTHDF1 and YTHDF3 bind to m6A‐marked G6pc mRNA to increase its synthesis. Hepatocyte‐specific deletion of Mettl14 decreases G6pc m6A methylation, G6pc biosynthesis, and G6pc‐mediated gluconeogenesis, alleviating glucose metabolic defects in ...
Qiantao Zheng, Xiao Zhong, Qianqian Kang, Zhiguo Zhang, Decheng Ren, Yong Liu, Liangyou Rui   +6 more
wiley   +1 more source

Beyond destruction: emerging roles of the E3 ubiquitin ligase Hakai

Cellular & Molecular Biology Letters
Hakai protein (CBLL1 gene) was identified as an E3 ubiquitin ligase of E-cadherin complex, inducing its ubiquitination and degradation, thus inducing epithelial-to-mesenchymal transition.
Juan-José Escuder-Rodríguez, Andrea Rodríguez-Alonso, Lía Jove, Macarena Quiroga, Gloria Alfonsín, Angélica Figueroa   +5 more
doaj   +1 more source

RNAFlow: RNA Structure & Sequence Design via Inverse Folding-Based Flow Matching [PDF]

arXiv
The growing significance of RNA engineering in diverse biological applications has spurred interest in developing AI methods for structure-based RNA design. While diffusion models have excelled in protein design, adapting them for RNA presents new challenges due to RNA's conformational flexibility and the computational cost of fine-tuning large ...
arxiv  

Direct adenylation from 5'-OH-terminated oligonucleotides by a fusion enzyme containing Pfu RNA ligase and T4 polynucleotide kinase. [PDF]

Nucleic Acids Res, 2022
Yang Z, Zhang C, Lian G, Dong S, Song M, Shao H, Wang J, Zhong T, Luo Z, Jin S, Ding C.   +10 more
europepmc   +1 more source

Distinct Functions of Two RNA Ligases in Active Trypanosoma brucei RNA Editing Complexes [PDF]

, 2002
Jorge Cruz‐Reyes, Alevtina G. Zhelonkina, Catherine Huang, Barbara Sollner-Webb   +3 more
openalex   +1 more source