Results 191 to 200 of about 1,338,157 (346)
Structure-function correlations derived from faster variants of a RNA ligase deoxyribozyme [PDF]
, 2004 Tracey K. Prior
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Advanced Science, EarlyView.The RBR E3 ubiquitin ligase ARIH1, which is upregulated in colorectal cancer cells, promotes cell growth and metastasis and correlates with an unfavorable CRC prognosis. Mechanistically, ARIH1 catalyzes K63‐linked ubiquitination of PHB1, enhancing the interaction between PHB1 and Akt.
Ying Tong +13 more
wiley +1 more source
A cis-acting ligase ribozyme generates circular RNA in vitro for ectopic protein functioning
Nature CommunicationsDelivering synthetic protein-coding RNA bypassing the DNA stage for ectopic protein functioning is a novel therapeutic strategy. Joining the linear RNA head-to-tail covalently could be a state-of-the-art strategy for functioning longer.
Chan-I Su +5 more
doaj +1 more source
Advanced Science, EarlyView.PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen +13 more
wiley +1 more source
An RNA condensate model for the origin of life [PDF]
arXivThe RNA World hypothesis predicts that self-replicating RNAs evolved before DNA genomes and coded proteins. Despite widespread support for the RNA World, self-replicating RNAs have yet to be identified in a natural context, leaving a key 'missing link' for this explanation of the origin of life.
arxiv
Cross-Catalytic Replication of an RNA Ligase Ribozyme [PDF]
, 2004 Dong‐Eun Kim, Gerald F. Joyce
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Advanced Science, EarlyView.The FGF13 level is significantly downregulated in premature aging murine hearts subject to D‐galactose and Doxorubicin. FGF13 overexpression and deficiency exacerbated and alleviated Doxorubicin/D‐galactose‐induced myocardial aging characteristics and functional impairment, respectively.
Enzhao Shen +15 more
wiley +1 more source
Emerging Roles of TRIM56 in Antiviral Innate Immunity
VirusesThe tripartite-motif protein 56 (TRIM56) is a RING-type E3 ubiquitin ligase whose functions were recently beginning to be unveiled. While the physiological role(s) of TRIM56 remains unclear, emerging evidence suggests this protein participates in host ...
Dang Wang, Kui Li
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An RNA Ligase from Deinococcus radiodurans [PDF]
, 2004 Alexandra Martins, Stewart Shuman
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MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer
Advanced Science, EarlyView.This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang +9 more
wiley +1 more source