Results 201 to 210 of about 1,338,157 (346)

Identification and Application of a Novel Patulin Degrading Enzyme From Meyerozyma guilliermondii

Advanced Science, EarlyView.
Patulin (PAT), a hazardous mycotoxin, threatens human health. A novel yeast‐derived short‐chain dehydrogenase/reductase effectively degrades PAT into nontoxic ascladiol via catalytic triad activity. The biological detoxification process has no significant effect on the quality of fresh pear juice.
Yu Zhang, Qianhua Zhao, Solairaj Dhanasekaran, Esa Abiso Godana, Yue Zhang, Xue Bai, Qiya Yang, Hongyin Zhang   +7 more
wiley   +1 more source

Establishment of a circRNA-regulated E3 ubiquitin ligase signature and nomogram to predict immunotherapeutic efficacy and prognosis in hepatocellular carcinoma

European Journal of Medical Research
Background Hepatocellular carcinoma (HCC) is a common type of malignant tumor where the prognosis is dismal. Circular RNA (CircRNA) is a novel RNA that regulates downstream gene transcription and translation to influence the progression of HCC.
Gefeng Wu, Jiahao Zhang, Rui Peng, Jun Cao, Daoyuan Tu, Jie Zhou, Bingbing Su, Shengjie Jin, Guoqing Jiang, Chi Zhang, Dousheng Bai   +10 more
doaj   +1 more source

Comprehensive benchmarking of large language models for RNA secondary structure prediction [PDF]

arXiv
Inspired by the success of large language models (LLM) for DNA and proteins, several LLM for RNA have been developed recently. RNA-LLM uses large datasets of RNA sequences to learn, in a self-supervised way, how to represent each RNA base with a semantically rich numerical vector.
arxiv  

New ligase-derived RNA polymerase ribozymes [PDF]

, 2005
Michael S. Lawrence, David P. Bartel
openalex   +1 more source

The MdHB7L–MdICE1L–MdHOS1 Module Fine‐Tunes Apple Cold Response via CBF‐Dependent and CBF‐Independent Pathways

Advanced Science, EarlyView.
In early cold response, MdICE1L utilizes MdHB7L as a cofactor to facilitate the transcriptional activation of MdCBFs, thereby activating cold signaling rapidly and strongly. Subsequently, MdICE1L is degraded by MdHOS1. Meanwhile, MdHB7L is released and accumulates.
Jie Yang, Na Li, Ming Li, Ran Yi, Lina Qiu, Kangning Wang, Shuang Zhao, Fengwang Ma, Ke Mao   +8 more
wiley   +1 more source

Structure and Mechanism of RNA Ligase

, 2004
C. Kiong Ho, Li‐Kai Wang, Christopher D. Lima, Stewart Shuman   +3 more
openalex   +2 more sources

RiboFlow: Conditional De Novo RNA Sequence-Structure Co-Design via Synergistic Flow Matching [PDF]

arXiv
Ribonucleic acid (RNA) binds to molecules to achieve specific biological functions. While generative models are advancing biomolecule design, existing methods for designing RNA that target specific ligands face limitations in capturing RNA's conformational flexibility, ensuring structural validity, and overcoming data scarcity.
arxiv  

Plant tRNA ligases are multifunctional enzymes that have diverged in sequence and substrate specificity from RNA ligases of other phylogenetic origins [PDF]

, 2005
Markus Englert
openalex   +1 more source

HDAC6 and USP9X Control Glutamine Metabolism by Stabilizing GS to Promote Glioblastoma Tumorigenesis

Advanced Science, EarlyView.
Glioblastoma (GBM) growth relies on glutamine synthetase (GS), which is stabilized by histone deacetylase 6 (HDAC6) and deubiquitinated by ubiquitin‐specific peptidase 9, X‐linked (USP9X). HDAC6 promotes GS deacetylation, while USP9X removes its K48‐linked polyubiquitination, enhancing GS stability.
Go Woon Kim, Minhae Cha, Hien Thi My Ong, Jung Yoo, Yu Hyun Jeon, Sang Wu Lee, Soo Yeon Oh, Min‐Jung Kang, Youngsoo Kim, So Hee Kwon   +9 more
wiley   +1 more source

The E3 Ubiquitin Ligase Mind Bomb 1 Controls Adenovirus Genome Release at the Nuclear Pore Complex

Cell Reports, 2019
Summary: Adenoviruses (AdVs) cause respiratory, ocular, and gastrointestinal tract infection and inflammation in immunocompetent people and life-threatening disease upon immunosuppression.
Michael Bauer, Justin W. Flatt, Daria Seiler, Bettina Cardel, Mario Emmenlauer, Karin Boucke, Maarit Suomalainen, Silvio Hemmi, Urs F. Greber   +8 more
doaj