Results 231 to 240 of about 1,353,045 (362)

Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells

Advanced Science, EarlyView.
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng, Jiayao Li, Wuke Wang, Dong Liang, Zhanwei Li, Cong Mao, Qingyang Li, Yu Zhang, Hao Chen, Jin Tang, Ping Hu, Qi Niu, Xingxu Huang, Bin Shen, Jun Zhang   +14 more
wiley   +1 more source

Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation. [PDF]

Proc Natl Acad Sci U S A
Hu Y, Lopez VA, Xu H, Pfister JP, Song B, Servage KA, Sakurai M, Jones BT, Mendell JT, Wang T, Wu J, Lambowitz AM, Tomchick DR, Pawłowski K, Tagliabracci VS.   +14 more
europepmc   +1 more source

A Blast‐Resistant NLR Gene Confers Drought Resistance by Competitively Interacting with an E3 Ligase to Protect Phenylalanine Ammonia‐Lyase in Rice

Advanced Science, EarlyView.
The NLR protein PibH8 interacts with phenylalanine ammonia‐lyase OsPAL1 and E3 ubiquitin ligase OsFBK16. Through competitive binding, PibH8 weakens the interaction between OsFBK16 and OsPAL1, thereby reducing the degradation of OsPAL1 by OsFBK16. The Hap1 allele of PibH8 exhibits a higher expression level than Hap2, thus accumulating more PibH8 protein,
Denghao Xiang, Haifu Tu, Yang Yuan, Yilong Yao, Wanwen Liao, Huaijun Wang, Yu Yan, Yao Wang, Yu Chen, Di Liu, Qingya Lv, Haidong He, Honghong Hu, Xuelei Lai, Meng Yuan, Haiyan Xiong, Faming Dong, Lizhong Xiong   +17 more
wiley   +1 more source

Evolution of the substrate specificity of an RNA ligase ribozyme from phosphorimidazole to triphosphate activation. [PDF]

Proc Natl Acad Sci U S A
DasGupta S, Weiss Z, Nisler C, Szostak JW.   +3 more
europepmc   +1 more source

tRNA Ligase Catalyzes the GTP-Dependent Ligation of RNA with3′-Phosphate and 5′-Hydroxyl Termini [PDF]

, 2012
Kevin K. Desai, Ronald T. Raines
openalex   +1 more source

Potential of circular RNA itchy E3 ubiquitin protein ligase as a biomarker and treatment target for multiple myeloma [PDF]

, 2020
Hui Zhou, Jie Zhang, Bihua Chen, Hengyu Liu, Xiyu Liu, Zhongyi Sun, Zhou Ouyang, Fang Zhou, Yajun Li, Junqiao He, Lijun Wang, Ruolan Zeng, Ling Xiao   +12 more
openalex   +1 more source

Making ends meet: a role of RNA ligase RTCB in unfolded protein response

EMBO Journal, 2014
W. Filipowicz
semanticscholar   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

A human RNA ligase that operates via auto- and RNA-AMPylation

, 2022
Yuan Y, Stumpf FM, Schlor LA, Schmidt OP, Huber LB, Frese M, Höllmüller E, Scheffner M, Stengel F, Diederichs K, Marx A.   +10 more
europepmc   +1 more source

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source