Results 251 to 260 of about 1,353,045 (362)

The Ubiquitin Ligase Riplet Is Essential for RIG-I-Dependent Innate Immune Responses to RNA Virus Infection

, 2010
Hiroyuki Oshiumi, Moeko Miyashita, Naokazu Inoue, Masaru Okabe, Misako Matsumoto, Tsukasa Seya   +5 more
openalex   +1 more source

The adenylyltransferase domain of bacterial Pnkp defines a unique RNA ligase family

Proceedings of the National Academy of Sciences of the United States of America, 2012
Paul C. Smith, L. Wang, Pravin A. Nair, S. Shuman   +3 more
semanticscholar   +1 more source

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

Advanced Science, EarlyView.
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu, Lin Jing, Yixin Li, Jinxing Zhou, Xiaohui Cui, Sen Li, Shijie Yang, Fangming Kan, Junfeng Du, Wentao Zhong, Sheng Yu, Ning Wang, Xing Jia, Junhui Li, Pan Nie, Zhenzhong Chen, Ying Han, Lingxi Jiang, Xiyun Yan, Hongxia Duan, Baiyong Shen   +20 more
wiley   +1 more source

Cleavage of 3'-terminal adenosine by archaeal ATP-dependent RNA ligase. [PDF]

Sci Rep, 2017
Yoshinari S, Liu Y, Gollnick P, Ho CK.
europepmc   +1 more source

Genome-Wide Regulations of the Preinitiation Complex Formation and Elongating RNA Polymerase II by an E3 Ubiquitin Ligase, San1

, 2021
Priyanka Barman, Rwik Sen, Amala Kaja, Jannatul Ferdoush, Shalini Guha, Chhabi K. Govind, Sukesh R. Bhaumik   +6 more
openalex   +2 more sources

LncDARS‐AS1 Regulates ATP1A1 Stability and Enhances Na+/K+ ATPase Activity to Promote Osteosarcoma Metastasis

Advanced Science, EarlyView.
This study identifies LncDARS‐AS1 as a novel oncogenic regulator that stabilizes ATP1A1 and enhances Na⁺/K⁺ ATPase activity, promoting osteosarcoma metastasis. Targeting the LncDARS‐AS1/ATP1A1/NKA axis, including pharmacological inhibition with digoxin, offers promising opportunities for the development of new therapeutic strategies against ...
Mingxian Xu, Jiatian Wei, Xiaoyu Feng, Qinkai Zhang, Jian Chen, Xinyue Wang, Xiudan Zhan, Bing Lu, Weitang Guo, Mingzhe Cheng, Renxuan Huang, Shao Xu, Changye Zou   +12 more
wiley   +1 more source

Identification of small molecules that are synthetically lethal upon knockout of the RNA ligase Rlig1 in human cells. [PDF]

RSC Chem Biol
Stumpf FM, Müller S, Marx A.
europepmc   +1 more source

Emerging RNA-binding roles in the TRIM family of ubiquitin ligases [PDF]

, 2019
Felix Preston Williams, Kevin Haubrich, Cecilia Perez-Borrajero, Janosch Hennig   +3 more
openalex   +1 more source

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation

Advanced Science, EarlyView.
Hijacking Host Kinase PIM1: A β‐Coronavirus (OC43) strategy to degrade IFNAR1 and evade antiviral immunity. Human β‐coronaviruses (OC43) exploit the proto‐oncoprotein PIM1 kinase to sabotage innate immunity. Viral RNA/proteins upregulate PIM1, which phosphorylates E3 ligase β‐TrCP1.
Qianya Wan, Lin Zhu, Cien Chen, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu, Yuxin Hou, Hin Chu, Yiran Wang, Sheng Chen, Mingyu Pan, Zongwei Cai, Ming‐liang He   +16 more
wiley   +1 more source

Archaeal 3′-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation

, 2011
Markus Englert, Kelly Sheppard, Aaron Aslanian, John R. Yates, Dieter Söll   +4 more
openalex   +1 more source