Results 271 to 280 of about 1,338,157 (346)
Diversity of ThDP‐Dependent Enzymes Forming Chiral Tertiary Alcohols
ChemBioChem, EarlyView.Chiral tertiary alcohols are widespread in nature and bioactive compounds; however, their asymmetric synthesis faces several challenges. This review outlines the toolbox of ThDP‐dependent enzymes able to produce tertiary alcohols through the formation of CC bond formation using ketones as acceptor substrates. Herein, the substrate scope, the diversity
Daniela Bjarnesen +4 more
wiley +1 more source
ChemBioChem, EarlyView.Bioactivity‐guided isolation led to the discovery of a potent and selective inhibitor of the phytopathogen Botrytis cinerea, pleosporacin (1), from mycelia extracts of the fungal strain Pleosporales sp. IBWF 020‐21. The biosynthesis of the nonribosomal cyclic lipodepsipeptide 1 was elucidated via heterologous reconstitution in Aspergillus oryzae ...
Carsten Wieder +6 more
wiley +1 more source
RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage. [PDF]
J Biol Chem, 2018 Soll JM +3 more
europepmc +1 more source
Bacteriophage T4-included anticodon-loop nuclease detected in a host strain restrictive to RNA ligase mutants [PDF]
, 1982 Borasio, Gian Domenico +2 more
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Advances in Isotope Labeling for Solution Nucleic Acid Nuclear Magnetic Resonance Spectroscopy
ChemPlusChem, EarlyView.Recent advances in the field of nucleic acid nuclear magnetic resonance (NMR) are presented. Stable isotope labeling protocols and new approaches to segmentally label nucleic acid with NMR‐active residues are summarized. The novel methods will have a strong impact on the future of nucleic acid NMR and the characterization of structure and dynamics of ...
Stefan Hilber +3 more
wiley +1 more source
Developmental Dynamics, EarlyView.Abstract Background Mutations in cohesins cause cohesinopathies such as Cornelia de Lange Syndrome (CdLS) and Roberts Syndrome (RBS). Prior findings demonstrate that Esco2 (a cohesin activator) and Smc3 (a core cohesin subunit) regulate the CRL4 E3 ubiquitin ligase. SMC3 mutations, however, account for a small percentage of CdLS.
Annie C. Sanchez +4 more
wiley +1 more source
European Journal of Heart Failure, EarlyView.The analysis workflow, findings and potential clinical consequences of iron deficiency in heart failure (HF). From 881 patients with worsening HF, whole blood transcriptome was analysed using the Affymetrix Human Transcriptome Array (HTA) 2.0. Subjects were stratified according to their transferrin saturation (TSAT) levels as iron‐deficient (TSAT <20%)
Niels Grote Beverborg +17 more
wiley +1 more source
Mitochondria‐Nuclear Crosstalk: Orchestrating mtDNA Maintenance
Environmental and Molecular Mutagenesis, EarlyView.ABSTRACT The mitochondria (mt) and nucleus engage in a dynamic bidirectional communication to maintain cellular homeostasis, regulating energy production, stress response, and cell fate. Anterograde signaling directs mt function, while retrograde signaling conveys metabolic and stress‐related changes from mt to the nucleus. Central to this crosstalk is
Ghazal Darfarin, Janice Pluth
wiley +1 more source