Results 31 to 40 of about 1,353,045 (362)
The RtcB RNA ligase is an essential component of the metazoan unfolded protein response. [PDF]
EMBO Rep, 2014 Kosmaczewski SG +8 more
europepmc +2 more sources
Viroid RNA redirects host DNA ligase 1 to act as an RNA ligase [PDF]
Proceedings of the National Academy of Sciences, 2012 Viroids are a unique class of noncoding RNAs: composed of only a circular, single-stranded molecule of 246–401 nt, they manage to replicate, move, circumvent host defenses, and frequently induce disease in higher plants. Viroids replicate through an RNA-to-RNA rolling-circle mechanism consisting of transcription of oligomeric viroid RNA ...
M. Nohales, R. Flores, J. Daròs
semanticscholar +4 more sources
RTP801 interacts with the tRNA ligase complex and dysregulates its RNA ligase activity in Alzheimer's disease. [PDF]
Nucleic Acids ResCampoy-Campos G +16 more
europepmc +2 more sources
New ligase-derived RNA polymerase ribozymes [PDF]
RNA, 2005 The search is underway for a catalytic RNA molecule capable of self-replication. Finding such a ribozyme would lend crucial support to the RNA World hypothesis, which holds that very early life-forms relied on RNA for both replicating and storing genetic information.
Michael S. Lawrence, David P. Bartel
openalex +4 more sources
Life, 2022 The acquisition of functions via the elongation of nucleotides is an important factor in the development of the RNA world. In our previous study, we found that the introduction of complementary seven-membered kissing loops into inactive R3C ligase ...
Hiromi Mutsuro-Aoki, Koji Tamura
doaj +1 more source
Mutational analysis of Trypanosoma brucei RNA editing ligase reveals regions critical for interaction with KREPA2. [PDF]
PLoS ONE, 2015 The Trypanosoma brucei parasite causes the vector-borne disease African sleeping sickness. Mitochondrial mRNAs of T. brucei undergo posttranscriptional RNA editing to make mature, functional mRNAs.
Vaibhav Mehta +3 more
doaj +1 more source
Molecular Cell, 2004 In the current issue of Structure, Ho and coworkers report the crystal structure and mechanism of a T4 RNA ligase. These studies provide valuable insights on the mechanism and origin of RNA and DNA ligases, and RNA capping enzymes.
Robert Sabatini +2 more
openaire +2 more sources
Diversity and roles of (t)RNA ligases [PDF]
Cellular and Molecular Life Sciences, 2012 The discovery of discontiguous tRNA genes triggered studies dissecting the process of tRNA splicing. As a result, we have gained detailed mechanistic knowledge on enzymatic removal of tRNA introns catalyzed by endonuclease and ligase proteins. In addition to the elucidation of tRNA processing, these studies facilitated the discovery of additional ...
Alexander Schleiffer +2 more
openaire +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2012 Anupam K. Chakravarty +3 more
openalex +2 more sources
An improved method for surface immobilisation of RNA: application to small Non-Coding RNA - mRNA pairing [PDF]
, 2013 Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and the ...
Butt, Louise +9 more
core +6 more sources