Results 31 to 40 of about 1,281,894 (266)

Ribozyme activity modulates the physical properties of RNA–peptide coacervates

eLife, 2023
Condensed coacervate phases are now understood to be important features of modern cell biology, as well as valuable protocellular models in origin-of-life studies and synthetic biology.
Kristian Kyle Le Vay, Elia Salibi, Basusree Ghosh, TY Dora Tang, Hannes Mutschler   +4 more
doaj   +1 more source

A streamlined protocol for the detection of mRNA–sRNA interactions using AMT-crosslinking in vitro

BioTechniques, 2019
Until recently, RNA–RNA interactions were mainly identified by crosslinking RNAs with interacting proteins, RNA proximity ligation and deep sequencing. Recently, AMT-based direct RNA crosslinking was established.
Rebecca Kirsch, V Janett Olzog, Sonja Bonin, Christina E Weinberg, Heike Betat, Peter F Stadler, Mario Mörl   +6 more
doaj   +1 more source

TRIM41-Mediated Ubiquitination of Nucleoprotein Limits Vesicular Stomatitis Virus Infection

Viruses, 2020
Vesicular stomatitis virus (VSV) is a zoonotic, negative-stranded RNA virus of the family Rhabdoviridae. The nucleoprotein (N) of VSV protects the viral genomic RNA and plays an essential role in viral transcription and replication, which makes the ...
Girish Patil, Lingling Xu, Yakun Wu, Kun Song, Wenzhuo Hao, Fang Hua, Lingyan Wang, Shitao Li   +7 more
doaj   +1 more source

The Role of ZAP and TRIM25 RNA Binding in Restricting Viral Translation

Frontiers in Cellular and Infection Microbiology, 2022
The innate immune response controls the acute phase of virus infections; critical to this response is the induction of type I interferon (IFN) and resultant IFN-stimulated genes to establish an antiviral environment.
Emily Yang, Emily Yang, LeAnn P. Nguyen, LeAnn P. Nguyen, Carlyn A. Wisherop, Ryan L. Kan, Ryan L. Kan, Melody M.H. Li, Melody M.H. Li, Melody M.H. Li   +9 more
doaj   +1 more source

Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner

Cell Reports, 2023
Summary: Type I interferon (IFN-I) signaling is central to inducing antiviral innate immunity. However, the mechanisms for IFN-I signaling self-regulation are still largely unknown.
Xianghui Kong, Xinliang Lu, Shibo Wang, Jiayue Hao, Danfeng Guo, Hao Wu, Yu Jiang, Yi Sun, Jianli Wang, Gensheng Zhang, Zhijian Cai   +10 more
doaj   +1 more source

Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation

Nature Communications, 2022
Cytoplasmic accumulation of RNA binding protein, hnRNPK in cancer cells is associated with poor prognosis. Here the authors show that SCFFbxo4 E3 ubiquitin ligase-mediated polyubiquitylation of hnRNPK restricts c-Myc translation and limits cancer ...
Bartosz Mucha, Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J. Nathaniel Diehl, Frank Tedeschi, Gao Zhou, Zhaofeng Gao, Samuel Flashner, Andres J. Klein-Szanto, Hanina Hibshoosh, Shimonosono Masataka, Olga S. Chajewski, Ireneusz Majsterek, Dariusz Pytel, Maria Hatzoglou, Channing J. Der, Hiroshi Nakagawa, Adam J. Bass, Kwok-Kin Wong, Serge Y. Fuchs, Anil K. Rustgi, Eckhard Jankowsky, J. Alan Diehl   +23 more
doaj   +1 more source

Reconciling Ligase Ribozyme Activity with Fatty Acid Vesicle Stability

Life, 2014
The “RNA world” and the “Lipid world” theories for the origin of cellular life are often considered incompatible due to the differences in the environmental conditions at which they can emerge.
Fabrizio Anella, Christophe Danelon
doaj   +1 more source

Viroid Replication: Rolling-Circles, Enzymes and Ribozymes

Viruses, 2009
Viroids, due to their small size and lack of protein-coding capacity, must rely essentially on their hosts for replication. Intriguingly, viroids have evolved the ability to replicate in two cellular organella, the nucleus (family Pospiviroidae) and the ...
Marcos De la Peña, Selma Gago, Alberto Carbonell, María-Ángeles Nohales, María-Eugenia Gas, Diego Molina-Serrano, José-Antonio Daròs, Ricardo Flores   +7 more
doaj   +1 more source

Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis

Nucleic Acids Research, 2016
An ATP-dependent RNA ligase from Methanobacterium thermoautotrophicum (MthRnl) catalyzes intramolecular ligation of single-stranded RNA to form a closed circular RNA via covalent ligase-AMP and RNA-adenylylate intermediate.
Huiqiong Gu, S. Yoshinari, R. Ghosh, Anna V. Ignatochkina, Paul D. Gollnick, Katsuhiko S. Murakami, C. Ho   +6 more
semanticscholar   +1 more source

CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication

mBio, 2017
Influenza A virus (IAV) RNA segments are individually packaged with viral nucleoprotein (NP) and RNA polymerases to form a viral ribonucleoprotein (vRNP) complex.
Yu-Chen Lin, King-Song Jeng, Michael M. C. Lai   +2 more
doaj   +1 more source