Results 151 to 160 of about 389,403 (285)

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Comparison of research trends and hotspots of DNA and RNA methylation in asthma-related studies based on bibliometric analysis

Discover Applied Sciences
Background Asthma is a prevalent chronic inflammatory disease, and recent research highlights the role of epigenetic modifications, such as DNA and RNA methylation, in its pathogenesis.
Junbao Du, Lifen Gong, Jialiang Wang, Ziwei Zhang, Hang Cheng   +4 more
doaj   +1 more source

Isocitrate dehydrogenase wt and IDHmut adult-type diffuse gliomas display distinct alterations in ribosome biogenesis and 2’O-methylation of ribosomal RNA

, 2023
Hermes Paraqindes, Nour‐El‐Houda Mourksi, Samantha Ballesta, Jordan Hedjam, Fleur Bourdelais, Tanguy Fenouil, Thiébaud Picart, Frédéric Catez, Théo Combe, Anthony Ferrari, Janice Kielbassa, Emilie Thomas, Laurie Tonon, Alain Viari, Valéry Attignon, Marjorie Carrère, Jessie Perrossier, Stéphane Giraud, Christophe Vanbelle, Mathieu Gabut, Danny Bergeron, Michelle S Scott, Luis Castro Vega, Nathalie Magne, Emmanuelle Huillard, Marc Sanson, David Meyronet, Jean‐Jacques Diaz, François Ducray, Virginie Marcel, Sébastien Durand   +30 more
openalex   +2 more sources

Investigation of the genetic effect of 56 tobacco-smoking susceptibility genes on DNA methylation and RNA expression in human brain [PDF]

, 2022
Zhongli Yang, Jiekun Yang, Ying Mao, Ming D. Li   +3 more
openalex   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Author response: Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells

, 2015
João D. Dias, Tiago Rito, Elena Torlai Triglia, Alexander Kukalev, Carmelo Ferrai, Mita Chotalia, Emily Brookes, Hiroshi Kimurâ, Ana Pombo   +8 more
openalex   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand‐Symmetric and ‐Asymmetric 5‐Hydroxymethylcytosine‐Modifications in DNA

Advanced Science, EarlyView.
ABSTRACT The cytosine (C) modifications 5‐methylcytosine (mC) and 5‐hydroxymethylcytosine (hmC) are central regulatory elements of mammalian genomes. Both marks occur in double‐stranded DNA in either strand‐symmetric or ‐asymmetric fashion, but it is still poorly understood how this symmetry information is selectively read out by the nuclear proteome ...
Lena Engelhard, Zeyneb Vildan Cakil, Marlon S. Zambrano‐Mila, Simone Eppmann, Tye Gonzalez, Rasmus Linser, Petra Janning, Sidney Becker, Daniel Summerer   +8 more
wiley   +1 more source

Middle-down proteomics reveals dense sites of methylation and phosphorylation in arginine-rich RNA-binding proteins [PDF]

, 2019
Sean R. Kundinger, Isaac Bishof, Eric B. Dammer, Duc M. Duong, Nicholas T. Seyfried   +4 more
openalex   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source