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RNA Nanostructures: From Structure to Function
Bioconjugate Chemistry, 2022Nucleic-acid nanostructures, which have been designed and constructed with atomic precision, have been used as scaffolds for different molecules and proteins, as nanomachines, as computational components, and more. In particular, RNA has garnered tremendous interest as a building block for the self-assembly of sophisticated and functional ...
Ofer I. Wilner +2 more
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DNA nanostructures directed by RNA clamps
Nanoscale, 2021DNA chains can be folded rationally by using DNA staples, and the programmed structures are of great potential in nanomaterial studies.
Jiazhen Lyu +6 more
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Assessment of Intracellular Compartmentalization of RNA Nanostructures
2023Nucleic acid nanoparticles (NANPs) are extensively investigated as diagnostic and therapeutic tools. These innovative particles can be composed of RNA, DNA, and/or modified nucleic acids. Due to the regulatory role of nucleic acids in the cellular system, NANPs have the ability to identify target molecules and regulate expression of genes in disease ...
Yasmine, Radwan +2 more
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Branched RNA nanostructures for RNA interference
Chemical Communications, 2011Branched RNAs with three- or four-way junctions were designed by assembling single-stranded RNA for RNA interference. Human Dicer transformed branched RNAs into about 20 base pairs of double-stranded RNA, which is a standard siRNA species. Our tetramer design provides a potent silencing effect over a period of 5 days.
Yuko, Nakashima +4 more
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RNA Nanostructure Molecular Imaging
2020Atomic force and transmission electron microscopies (AFM/TEM) are powerful tools to analyze RNA-based nanostructures. While cryo-TEM analysis allows the determination of near-atomic resolution structures of large RNA complexes, this chapter intends to present how RNA nanostructures can be analyzed at room temperature on surfaces.
Pietrement, Olivier +2 more
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Nano Letters, 2018 Molecular complexes composed of RNA molecules and proteins are promising multifunctional nanostructures for a wide variety of applications in biological cells or in artificial cellular systems.
Aurore Dupin +2 more
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Self-assembled RNA nanostructures
Science, 2014RNA structures have been designed that self-assemble and are programmable and scalable [Also see Report by Geary et al. ]
Leontis, N, Westhof, Eric
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A Nanostructure Made of a Bacterial Noncoding RNA
Journal of the American Chemical Society, 2009Natural RNAs, unlike many proteins, have never been reported to form extended nanostructures, despite their wide variety of cellular functions. This is all the more striking, as synthetic DNA and RNA forming large nanostructures have long been successfully designed. Here, we show that DsrA, a 87-nt noncoding RNA of Escherichia coli, self-assembles into
Cayrol, Bastien +5 more
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Nanostructured RNAs for RNA Interference
2014We synthesized three types of nanostructured RNAs that induce RNA interference (RNAi): branched RNAs, dumbbell-shaped RNA, and circular double-stranded RNAs. All three nanostructured RNAs were transformed into double-stranded RNA of approximately 20 base pairs when they were treated with nuclease enzymes such as Dicer.
Yuko, Nakashima +3 more
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