Results 161 to 170 of about 883,773 (191)

RNA Origami Nanostructures for Potent and Safe Anticancer Immunotherapy

ACS Nano, 2020
Abstract Rapid developments in nucleic acid nanotechnology have enabled the rational design and construction of self-assembling DNA and RNA nanostructures that are highly programmable. We recently developed a replicable single-stranded RNA origami (RNA-OG) technology that allows a long RNA molecule to be programmed to self-assemble ...
Xiaodong Qi, Xiaowei Liu, Lawrence Matiski, Ryan Rodriguez Del Villar, Theresa Yip, Fei Zhang, Sriram Sokalingam, Shuoxing Jiang, Li Liu, Hao Yan, Yung Chang   +10 more
openaire   +2 more sources

Protocols for Molecular Dynamics Simulations of RNA Nanostructures

2017
Molecular dynamics (MD) simulations have been used as one of the main research tools to study a wide range of biological systems and bridge the gap between X-ray crystallography or NMR structures and biological mechanism. In the field of RNA nanostructures, MD simulations have been used to fix steric clashes in computationally designed RNA ...
Taejin, Kim, Wojciech K, Kasprzak, Bruce A, Shapiro   +2 more
openaire   +2 more sources

Automated 3D Design and Evaluation of RNA Nanostructures with RNAMake

2023
Despite growing interest in applying RNA's unique structural characteristics to solve diverse biotechnology and nanotechnology problems, there are few computational tools for targeted tertiary design. As a result, RNA 3D design is traditionally slow, resource-consuming, and dependent on expert modeling.
Chris P, Jurich, Joseph D, Yesselman
openaire   +2 more sources

Design, Assembly, and Evaluation of RNA–Protein Nanostructures

2015
The use of RNA-protein interaction motifs (RNP motifs) to design and build nanoscale objects has the potential to expand the field of RNA nanotechnology. In principle, RNP motifs can be integrated easily into RNA nano objects, providing an alternative technique to increase the functional and structural complexities of the RNA.
Hirohisa, Ohno, Eriko, Osada, Hirohide, Saito   +2 more
openaire   +2 more sources

Design and Crystallography of Self-Assembling RNA Nanostructures

2017
Biological RNA architectures are composed of autonomously folding modules which can be tailored as building blocks for the construction of RNA nanostructures. Designed base pair interactions allow complex nano-objects to self-assemble from simple RNA motifs.
Mark A, Boerneke, Thomas, Hermann
openaire   +2 more sources

Folding RNA–Protein Complex into Designed Nanostructures

2015
RNA-protein (RNP) complexes are promising biomaterials for the fields of nanotechnology and synthetic biology. Protein-responsive RNA sequences (RNP motifs) can be integrated into various RNAs, such as messenger RNA, short-hairpin RNA, and synthetic RNA nano-objects for a variety of purposes.
Tomonori, Shibata, Yuki, Suzuki, Hiroshi, Sugiyama, Masayuki, Endo, Hirohide, Saito   +4 more
openaire   +3 more sources

An Efficient Thermally Induced RNA Conformational Switch as a Framework for the Functionalization of RNA Nanostructures

Journal of the American Chemical Society, 2006
RNA offers a variety of interactions and dynamic conformational switches not available with DNA that may be exploited for the construction of nanomolecular structures. Here, we show how the RNA loop-loop, or "kissing", interaction can be used to construct specific circular RNA arrangements that are capable of thermal isomerization to alternative ...
Xianglan, Li, Satoru, Horiya, Kazuo, Harada   +2 more
openaire   +2 more sources

Encapsulation of RNA with DNA Six-Helix Bundle Nanostructures

Nano Letters
A DNA six-helix bundle (6HB) was used as the "RNaseproof" sheath for RNA encapsulation and mimics the helical virus capsid for RNA protection. As a widely used motif in the field of DNA nanotechnology, DNA 6HB contains a cavity with a size of ∼2 nm. Previously, DNA 6HB was used to incorporate a DNA duplex inside of the cavity.
Yihan Lv, Yican Wei, Xiao Wang
openaire   +2 more sources

RNA Nanostructures

2023
openaire   +1 more source

Role of Dynamics in RNA Nanostructure Design

2013
One of the goals of RNA-based nanotechnology is the development of smart molecules capable of disrupting oncogenic and disease molecular pathways in a selective way. RNA is well suited to combining structural scaffolds and active agents made out of the same building material.
openaire   +1 more source