Results 111 to 120 of about 966,777 (273)

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

The National Nanotechnology Initiatives at 5 Years: Assessment and Recommendations of the National Nanotechnology Advisory Panel

, 2005
The National Nanotechnology Initiative (NNI) was established in 2001 to coordinate federal nanotechnology research and development (R&D). In this review of the NNI, the President’s Council of Advisors on Science and Technology (PCAST) determines that the
National Nanotechnology Advisory Panel
core  

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Targeting the Eye: RNA-Based Therapies, Interferences, and Delivery Strategies

Pharmaceutics
Recent advances in molecular biology have led to the development of RNA-based therapeutics, offering significant promise for treating various eye diseases.
Mohammed S. Abdel-Raziq Hassan, Cheng Zhong, Fatma Hassan, S. Kevin Li   +3 more
doaj   +1 more source

RNA Nanotechnology for Reversal of Melanoma Immunotherapy Resistance

Purpose: Cancer immunotherapy works by targeting immune and cancer cell checkpoints to induce long-term anti-tumor responses, showing effectiveness in inhibiting tumor growth and preventing recurrence.
Mehdi Karimi-Shahri, Mojtaba Tarin, Mahsa Akbari Oryani, Hossein Javid, Sareh Etemad, Amirhossein Ebadi   +5 more
core   +1 more source

Gestalt Switch in Molecular Image Perception: The Aesthetic Origin of Molecular Nanotechnology in Supramolecular Chemistry [PDF]

, 2004
According to ‘standard histories’ of nanotechnology, the colorful pictures of atoms produced by scanning probe microscopists since the 1980s essentially inspired visions of molecular nanotechnology.
Schummer, Joachim
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A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy

Advanced Science, EarlyView.
A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao, Yufei Lan, Min‐Goo Lee, Jinjun He, Yueran Pan, Eunji Kim, Xin Fu, Sungwook Jung, Wanxia Lu, Jinyue Fan, Haoxiang Chen, Yuanbo Zhao, Yuling Xu, Jong Seung Kim, Chao Zhang   +14 more
wiley   +1 more source

Nanotechnology Enhanced RNAi Therapies in Cancer: A Systematic Review

Journal of Cancer Biomoleculars and Therapeutics
Cancer remains a major cause of illness and death worldwide, with conventional treatments often hindered by systemic toxicity, lack of specificity, and the development of resistance.
Muhammad Abid Mustafa, Namra Rasheed
doaj   +1 more source

Nanotechnology applied to bio-encapsulation of pesticides

, 2016
In recent years, many efforts have been made towards the application of nanotechnology in sustainable food production. In this context, the bio-encapsulation process has taken prominence in particular as an ecofriendly method for pest control while ...
Fraceto, Leonardo Fernandes [UNESP], Abhilash, Purushothaman Chirakkuzhyil, Grillo, Renato [UNESP]   +2 more
core   +1 more source