A global function for transcription factors in assisting RNA polymerase II termination. [PDF]
, 2017 The role of transcription factors (TFs) on nucleosome positioning, RNA polymerase recruitment, and transcription initiation has been extensively characterized.
Chanfreau, Guillaume F, Roy, Kevin
core +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source
Dynamics of Matrix Metalloproteinase-9 Levels in the Novel Coronavirus Infection COVID-19
Антибиотики и ХимиотерапияBackground. It has been established that metalloproteinase-9 (hereinafter MMP-9) is the most inducible enzyme of the metalloproteinase family. It regulates the migration of leukocytes to the site of inflammation, participates in the stimulation of pro ...
A. U. Sabitov +5 more
doaj +1 more source
Klebsiella Phage KP34 RNA Polymerase and Its Use in RNA Synthesis
Frontiers in Microbiology, 2019 We have characterized the single subunit RNA polymerase from Klebsiella phage KP34. The enzyme is unique among known bacteriophage RNA polymerases in that it recognizes two unrelated promoter sequences, which provided clues for the evolution of phage ...
Xueling Lu +8 more
doaj +1 more source
Production of positive controls for calcivirus-specific PCR using recombinant baculiovirus technology [PDF]
, 1997 Recent advances in our knowledge of the genetic structure of human caliciviruses (HuCVs) and small round-structured viruses (SRSVs) have led to the development of polymerase chain reaction (PCR)-based molecular tests specific for these viruses.
Butcher, S.A., Gould, E.A.
core
HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors [PDF]
, 2005 RNA and DNA aptamers specific for HIV-1 reverse transcriptase (RT) can inhibit reverse transcription in vitro. RNA aptamers have been shown to potently block HIV-1 replication in culture.
Fisher, Timothy S +2 more
core +3 more sources
Imaging RNA polymerase III transcription using a photostable RNA-fluorophore complex
Nature Chemical Biology, 2017 Quantitative measurement of transcription rates in live cells is important for revealing mechanisms of transcriptional regulation. This is particularly challenging for measuring the activity of RNA polymerase III (Pol III), which transcribes growth ...
Wenjiao Song +6 more
semanticscholar +1 more source
Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases [PDF]
BMC Structural Biology, 2003 The eukaryotic RNA-dependent RNA polymerase (RDRP) is involved in the amplification of regulatory microRNAs during post-transcriptional gene silencing. This enzyme is highly conserved in most eukaryotes but is missing in archaea and bacteria. No evolutionary relationship between RDRP and other polymerases has been reported so far, hence the origin of ...
Lakshminarayan M. Iyer +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Open Veterinary JournalBackground: Mycobacterium tuberculosis (Mtb), a pathogen that belongs to the M. tuberculosis complex (MTBC), causes tuberculosis (TB), an infectious bacterial disease.
Maged Fouda +5 more
doaj +1 more source