Results 141 to 150 of about 829,079 (264)

Microsecond Dynamics of the Pyrophosphate Ion Release in SARS-CoV‑2 RNA Polymerase. [PDF]

JACS Au
Xu T, Yang L, Xu X, Zhang BY, Gao X, Ishbashi T, Gong P, Cheung PP, Zhang L.   +8 more
europepmc   +1 more source

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries. [PDF]

Science
Ling YH, Liang C, Wang S, Wu C.
europepmc   +1 more source

Self‐Assembled Skin Equivalents with Monoclonal CRISPR/Cas9‐Modified N/TERT‐1 Keratinocytes: A Cutting‐Edge model for Human Skin and its Diseases

Advanced Healthcare Materials, EarlyView.
Self‐assembled, scaffold‐free full‐thickness skin equivalents with monoclonal, genetically modified N/TERT‐1 keratinocytes represent a novel in vitro model of human skin and skin diseases. The model is highly robust, reproducible, physiologically relevant, and suitable for high‐throughput applications.
Marta Slaufova, Tugay Karakaya, Michela Di Filippo, Thomas Kündig, Hans‐Dietmar Beer   +4 more
wiley   +1 more source

Emerging roles of POLR2L of RNA polymerase II dynamics and disease mechanisms (Review). [PDF]

Mol Med Rep
Lee B, Son C, Eom S, Li Y, Kim SH, Park J.   +5 more
europepmc   +1 more source

Adaptable Covalent Organic Framework‐Hydrogel Microneedles for Glucose‐Responsive Isoliquiritigenin Delivery in Diabetic Wound Therapy

Advanced Healthcare Materials, EarlyView.
We develop a covalent organic framework‐loaded Traditional Chinese Medicine monomer nanodrug delivery system (ISL@bCOF) via boron‐oxygen bonds, a smart response to glucose for delivering AI‐driven isoliquiritigenin (ISL) targeting ZBP1. This dynamic release mechanism, combined with transdermal delivery technology via potent microneedles, can modulate ...
Menghan Zhou, Zongjie Hu, Xiuwen Li, Huaman Geng, Yang Liu, Yajie Wang, Yunshu Yang, Guangdong Zhou, Yujie Hua, Di Wang   +9 more
wiley   +1 more source

Human FUS is toxic via association with RNA polymerase II in Drosophila. [PDF]

Cell Death Dis
Moens TG, Biasetti L, Scheveneels W, Smith BN, Troakes C, Van Damme P, Vance C, Van Den Bosch L.   +7 more
europepmc   +1 more source

Viral Infection‐Inspired Autonomous Detection of Fusion‐Competent Viruses for Screening and Environmental Surveillance

Advanced Materials, EarlyView.
Inspired by viral entry mechanisms, the FUSION assay enables autonomous detection of respiratory viruses via membrane fusion–triggered CRISPR‐Cas13a activation. VEACON selectively fuses with fusion‐competent viruses, triggering fluorescence within confined vesicles.
Jae Chul Park, Yidam Song, Hyun‐Woo Choi, Jaeuk Sung, Harin Jin, WonSeok Gwak, Kirim Yoo, Soohwang Lee, Jongeon Park, Jeongmin Kim, Hye‐Jun Jo, Jahyun Koo, Youngdo Jeong, Kwan Hyi Lee, Seung‐Jung Kee, Hojun Kim   +15 more
wiley   +1 more source

Genetic dissection of transcription start site selection by RNA polymerase II in Saccharomyces cerevisiae. [PDF]

Genetics
Arora P, Brennan KF, Warner MH, Kaplan CD.   +3 more
europepmc   +1 more source

Sensitive and Spatially‐Resolved Electrochemiluminescence via Micropatterning

Advanced Materials Interfaces, EarlyView.
The use of a simple silica nanoparticle surface coating and patterning process can transform ordinary gold electrodes into multiplexed ECL sensing electrodes. Through spatially confined droplet formation and local ECL emission, it is possible to perform multiple analyses simultaneously from individual locations as well as intensify the ECL signal by as
Yuliang Shao, Tatiana Starikova, Mengzhen Xi, Maria Vittoria Balli, Emanuele Luigi Sciuto, Gabriele Giagu, Vincenzo Paratore, Carmelo Corsaro, Enza Fazio, Sabrina Conoci, Luca Prodi, Giovanni Valenti, Pavel A. Levkin   +12 more
wiley   +1 more source