Results 151 to 160 of about 829,079 (264)

The KMT2F histone methyltransferase interacts with the RNA polymerase I machinery to promote ribosomal RNA transcription. [PDF]

PLoS Biol
Lone KA, Karole AM, Ravindran G, Tyagi S.   +3 more
europepmc   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

RNA Polymerase 1 inhibitors against African trypanosomes <i>in vitro</i> and in mice. [PDF]

Antimicrob Agents Chemother
Cumming AV, Nenortas NP, Nenortas E, Bakshi RP, Caton ER, Rios-Guzman E, Barry ME, Barrow JC, Laiho M, Shapiro TA.   +9 more
europepmc   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Cytosolic DNA inhibits rDNA transcription by retaining the RNA polymerase I transcription machinery. [PDF]

EMBO J
Xu Y, Wang Q, Qian C, Lu S, He Z, Liu W, Wan W.   +6 more
europepmc   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Cleavage of the RNA polymerase II general transcription factor TFIIB tunes transcription during stress. [PDF]

Genes Dev
Gulyas L, Lari A, Shah SB, Glaunsinger BA.   +3 more
europepmc   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Inhibitors of the hepatitis C virus RNA-dependent RNA polymerase

ARKIVOC, 2006
Barbara Attenni, Salvatore Avolio, Stefania Colarusso, Savina Malancona, Steven Harper, Sergio Altamura, Uwe Koch, Frank Narjes   +7 more
doaj   +1 more source

Dynamic landscape of transcription initiation by yeast RNA polymerase I. [PDF]

Nucleic Acids Res
Parilova O, Bartos P, Malinen AM.
europepmc   +1 more source