Results 201 to 210 of about 829,079 (264)

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Deep learning-guided dual-fitness evolution of T7 RNA polymerase for enhanced stability and activity. [PDF]

Nucleic Acids Res
Jiang F, Kang L, Li M, Zhong B, Chen X, Wu B, Li M, Yu Y, Hong L.   +8 more
europepmc   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

RNA Polymerase III Regulates HIV Replication and Latency. [PDF]

Viruses
Thompson L, Jamal I, Das J, Dang C, Hong Z, Katz D, Bosque A, Singh VB.   +7 more
europepmc   +1 more source

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Mfd interacts with RNA polymerase to modulate flagellum-dependent motility, chemotaxis, and population heterogeneity in the stationary phase of <i>Bacillus subtilis</i>. [PDF]

J Bacteriol
Grifaldo J, Leyva-Sanchez H, Rosales K, Callaway A, Sotelo A, Martin HA, Perez RK, Chavez Rios J, Huezo EN, Pedraza-Reyes M, Robleto EA.   +10 more
europepmc   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

A noncanonical RNA polymerase assembly pathway in Bacillus subtilis: α Dimer associates with either β or β' before forming the core enzyme. [PDF]

J Biol Chem
Tewary A, Chakraborty A, Sur R, Mukhopadhyay J.   +3 more
europepmc   +1 more source

The bacterial RNA polymerase-associated CarD protein couples promoter activity to DNA supercoiling. [PDF]

Nat Commun
Forrest D, Warman EA, Grainger DC.
europepmc   +1 more source