Results 51 to 60 of about 2,706,723 (382)
Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir
Viruses, 2019 Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug that shows broad-spectrum antiviral activity against several RNA viruses. This compound is currently under clinical development for the treatment of Ebola virus disease (
E. Tchesnokov +3 more
semanticscholar +1 more source
RNA polymerase interactions and elongation rate
, 2018 We show that non-steric molecular interactions between RNA polymerase (RNAP) motors that move simultaneously on the same DNA track determine strongly the kinetics of transcription elongation.
Belitsky, V., Schütz, G. M.
core +1 more source
Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2017 Favipiravir (T-705; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) is an anti-viral agent that selectively and potently inhibits the RNA-dependent RNA polymerase (RdRp) of RNA viruses.
Y. Furuta, T. Komeno, Takaaki Nakamura
semanticscholar +1 more source
Frontiers in Bioscience-LandmarkAccurate gene expression is fundamental for sustaining life, enabling adaptive responses to routine tasks and management of urgent cellular environments.
Jihye Ryu, Chaeyoung Lee
doaj +1 more source
Origin and Evolution of RNA-Dependent RNA Polymerase
Frontiers in Genetics, 2017 RNA-dependent RNA polymerases (RdRp) are very ancient enzymes and are essential for all viruses with RNA genomes. We reconstruct the origin and evolution of this polymerase since the initial stages of the origin of life. The origin of the RdRp was traced
Savio T. de Farias +3 more
doaj +1 more source
Biomolecular Concepts, 2016 The bacterial RNA polymerase (RNAP) holoenzyme is a multisubunit core enzyme associated with a σ factor that is required for promoter-specific transcription initiation. Besides a primary σ responsible for most of the gene expression during active growth,
Cavaliere Paola, Norel Françoise
doaj +1 more source
A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]
, 2014 There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Ahn +62 more
core +1 more source
In vitro Assessment of RNA Polymerase I Activity
Bio-Protocol, 2017 In eukaryotic cells transcriptional processes are carried out by three different RNA polymerases: RNA polymerase I which specifically transcribes ribosomal RNA (rRNA), RNA polymerase II which transcribes protein-coding genes to yield messenger RNAs ...
Marzia Govoni
doaj +1 more source
Reticulocyte RNA-Dependent RNA Polymerase [PDF]
Proceedings of the National Academy of Sciences, 1973 A cytoplasmic, microsomal bound RNA-dependent RNA polymerase has been purified 2500-fold from rabbit reticulocyte lysates. The synthesis of RNA with the purified enzyme is absolutely dependent on the addition of an RNA template. The best template is hemoglobin messenger RNA, while bacteriophage RNA and poly(A,G) are less active, and DNA is completely ...
Antero G. So +3 more
openaire +3 more sources
Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes
FEBS Letters, EarlyView.Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley +1 more source