Reciprocating RNA Polymerase batters through roadblocks
Nature CommunicationsRNA polymerases must transit through protein roadblocks to produce full-length transcripts. Here we report real-time measurements of Escherichia coli RNA polymerase passing through different barriers. As intuitively expected, assisting forces facilitated,
Jin Qian +7 more
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Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase
Nature Communications, 2017 The Zika virus outbreak is a global health threat and there is an urgent need for drugs against the virus. Here the authors present the structure of the RNA-dependent RNA-polymerase domain from Zika non-structural protein 5, which is a template for the ...
Andre S. Godoy +6 more
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Residue profile in predivergence sequences as a guide to the origin of DNA replication [PDF]
arXiv, 1999 DNA dependent RNA polymerase core subunits abb' conserved residues at frequencies most closely matched with codons at stage 10.4-11.1 in code evolution. An excess of acidic residues (stage 2 additions) lowered this estimate, but not by more than 2.3 stages.
arxiv
SARS-CoV-2 and miRNA-like inhibition power [PDF]
arXiv, 2020 (1) Background: RNA viruses and especially coronaviruses could act inside host cells not only by building their own proteins, but also by perturbing the cell metabolism. We show the possibility of miRNA-like inhibitions by the SARS-CoV-2 concerning for example the hemoglobin and type I interferons syntheses, hence highly perturbing oxygen distribution ...
arxiv
Viruses, 2016 An influenza virus polymerase reconstitution assay based on the human, dog, or chicken RNA polymerase I (PolI) promoter has been developed and widely used to study the polymerase activity of the influenza virus in corresponding cell types. Although it is
Gang Lu +5 more
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RNA polymerase motors on DNA track: effects of traffic congestion on RNA synthesis [PDF]
arXiv, 2007 RNA polymerase (RNAP) is an enzyme that synthesizes a messenger RNA (mRNA) strand which is complementary to a single-stranded DNA template. From the perspective of physicists, an RNAP is a molecular motor that utilizes chemical energy input to move along the track formed by a ssDNA.
arxiv
RNA polymerase motor on DNA track: effects of interactions, external force and torque [PDF]
arXiv, 2008 RNA polymerase (RNAP) is a mobile molecular workshop that polymerizes a RNA molecule by adding monomeric subunits one by one, while moving step by step on the DNA template itself. Here we develop a theoretical model by incorporating the steric interactions of the RNAPs and their mechanochemical cycles which explicitly captures the cyclical shape ...
arxiv
Seapration of B. subtilis DNA into complementary strands. II. Template functions and composition as determined by transcription with RNA polymerase. [PDF]
, 1968 J D Karkas, Rivka Rudner, Erwin Chargaff
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Effects of cations on DNA-dependent RNA polymerase. [PDF]
, 1967 Antero G. So +3 more
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POLIOVIRUS-INDUCED RNA POLYMERASE AND THE EFFECTS OF VIRUS-SPECIFIC INHIBITORS ON ITS PRODUCTION [PDF]
, 1963 David Baltimore +3 more
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