Results 101 to 110 of about 1,401,767 (284)
PLoS Pathogens, 2023 LGP2 is a RIG-I-like receptor (RLR) known to bind and recognize the intermediate double-stranded RNA (dsRNA) during virus infection and to induce type-I interferon (IFN)-related antiviral innate immune responses.
Zhongyuan Tan +11 more
doaj +1 more source
Crystal structure of the 14-subunit RNA polymerase I
Nature, 2013 Protein biosynthesis depends on the availability of ribosomes, which in turn relies on ribosomal RNA production. In eukaryotes, this process is carried out by RNA polymerase I (Pol I), a 14-subunit enzyme, the activity of which is a major determinant of ...
C. Fernández‐Tornero +8 more
semanticscholar +1 more source
Current Issues in Molecular Biology, 2022 The COVID-19 pandemic necessitated an extensive testing for active SARS-CoV-2 infection. However, securing affordable diagnostic tests is a struggle for low-resource settings.
Dana Abdalghani AbuObead +12 more
doaj +1 more source
Interchangeable RNA polymerase I and II enhancers. [PDF]
Proceedings of the National Academy of Sciences, 1990 The RNA polymerase I (pol I) enhancer of Saccharomyces cerevisiae contains at least three elements commonly associated with RNA polymerase II (pol II) enhancers, binding sites for the transcriptional activators general regulatory factor 2 and autonomously replicating sequence-binding factor I, and a thymidine-rich element.
Neal F. Lue +2 more
openaire +3 more sources
Residue profile in predivergence sequences as a guide to the origin of DNA replication [PDF]
arXiv, 1999 DNA dependent RNA polymerase core subunits abb' conserved residues at frequencies most closely matched with codons at stage 10.4-11.1 in code evolution. An excess of acidic residues (stage 2 additions) lowered this estimate, but not by more than 2.3 stages.
arxiv
How the Avidity of Polymerase Binding to the -35/-10 Promoter Sites Affects Gene Expression [PDF]
, 2019 Although the key promoter elements necessary to drive transcription in Escherichia coli have long been understood, we still cannot predict the behavior of arbitrary novel promoters, hampering our ability to characterize the myriad of sequenced regulatory architectures as well as to design novel synthetic circuits.
arxiv +1 more source
Efficient termination of transcription by RNA polymerase I requires the 5 ' exonuclease Rat1 in yeast [PDF]
, 2008 During transcription termination by RNA polymerase II on protein-coding genes, the nuclear 5′ exonuclease Rat1/Xrn2 degrades the nascent transcript downstream from the polyadenylation site and “torpedoes” the polymerase.
El Hage, Aziz +3 more
core +2 more sources
Bayesian inference of polymerase dynamics over the exclusion process [PDF]
arXiv, 2021 Transcription is a complex phenomenon that permits the conversion of genetic information into phenotype by means of an enzyme called RNA polymerase, which erratically moves along and scans the DNA template. We perform Bayesian inference over a paradigmatic mechanistic model of non-equilibrium statistical physics, i.e., the asymmetric exclusion ...
arxiv
Biochemistry, 2017 All cellular RNA polymerases are influenced by protein factors that stimulate RNA polymerase-catalyzed cleavage of the nascent RNA. Despite divergence in amino acid sequence, these so-called "cleavage factors" appear to share a common mechanism of action.
F. Appling, D. Schneider, A. Lucius
semanticscholar +1 more source
Transcription-translation machinery -- an autocatalytic network coupling all cellular cycles and generating a plethora of growth laws [PDF]
arXiv, 2021 Recently discovered simple quantitative relations, known as bacterial growth laws, hint on the existence of simple underlying principles at the heart of bacterial growth. In this work, we provide a unifying picture on how these known relations, as well as new relations that we derive, stems from a universal autocatalytic network common to all bacteria,
arxiv