A 212-nt long RNA structure in the Tobacco necrosis virus-D RNA genome is resistant to Xrn degradation [PDF]
, 2019 Plus-strand RNA viruses can accumulate viral RNA degradation products during infections. Some of these decay intermediates are generated by the cytosolic 5′-to-3′ exoribonuclease Xrn1 (mammals and yeast) or Xrn4 (plants) and are formed when the enzyme ...
Chaminda, Gunawardene D. +2 more
core +1 more source
The Replicase Protein of Potato Virus X Is Able to Recognize and Trans-Replicate Its RNA Component
VirusesThe trans-replication system explores the concept of separating the viral RNA involved in the translation of the replicase protein from the replication of the viral genome and has been successfully used to study the replication mechanisms of alphaviruses.
Pinky Dutta +3 more
doaj +1 more source
Cell-cycle dependent organization and dynamics of RNA Polymerase I in live human cells [PDF]
, 2017 RNA Polymerase I (Pol I) is responsible for over 60% of transcriptional output in human cells, yet basic questions concerning the spatial and temporal organization of the polymerase remain unanswered. Here we investigate how mammalian cells rely on Pol I
Cho, Won-Ki +4 more
core
Activation and repression of transcription by differential contact: two sides of a coin [PDF]
, 1998 Activation and repression of transcription are primarily caused by gene regulatory proteins (activators and repressors), which act by binding to specific sites on DNA.
Adhya, Sankar +2 more
core +1 more source
Stochastic Models of Regulation of Transcription in Biological Cells [PDF]
arXiv, 2022 In this paper we study an important global regulation mechanism of transcription of biological cells using specific macro-molecules, 6S RNAs. The functional property of 6S RNAs is of blocking the transcription of RNAs when the environment of the cell is not favorable.
arxiv
Localisation of the Ki-67 antigen within the nucleolus: Evidence for a fibrillarin-deficient region of the dense fibrillar component [PDF]
, 1996 The Ki-67 antigen is detected in proliferating cells in all phases of the cell division cycle. Throughout most of interphase, the Ki-67 antigen is localised within the nucleolus.
Kill, IR
core
Human Transcription Release Factor 2 Dissociates RNA Polymerases I and II Stalled at a Cyclobutane Thymine Dimer [PDF]
, 1999 RNA polymerase II stalled at a lesion in the transcribed strand is thought to constitute a signal for transcription-coupled repair. Transcription factors that act on RNA polymerase in elongation mode potentially influence this mode of repair. Previously,
Hara, Ryujiro +4 more
core +2 more sources
Enhancement of soybean RNA polymerase I by auxin. [PDF]
Proceedings of the National Academy of Sciences, 1975 When etiolated soybean seedlings are treated with the synthetic auxin, 2,4-dichlorophenoxy-acetic acid, cells of the mature hypocotyl become swollen and proliferate abnormally. This abnormal growth induced by auxin coincides with a 5- to 8-fold increase in the alpha-amanitin-insensitive RNA polymerase associated with isolated chromatin or nuclei.
Ron T. Nagao +4 more
openaire +2 more sources
Cell Cycle, 2014 Mutations in the Cockayne syndrome A (CSA) protein account for 20% of Cockayne syndrome (CS) cases, a childhood disorder of premature aging and early death.
S. Koch +6 more
semanticscholar +1 more source
Theoretical analysis of transcription process with polymerase stalling [PDF]
arXiv, 2015 Experimental evidences show that in gene transcription, RNA polymerase has the possibility to be stalled at certain position of the transcription template. This may be due to the template damage, or protein barriers. Once stalled, polymerase may backtrack along the template to the previous nucleotide to wait for the repair of the damaged site, or ...
arxiv