Results 111 to 120 of about 807,500 (308)
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Structure of the initiation-competent RNA polymerase I and its implication for transcription
Nature Communications, 2016 Eukaryotic RNA polymerase I (Pol I) is responsible for the transcription of rRNA genes. Here the authors determine the cryo-EM structure of the Pol I-Rrn3 complex, providing insight into how Rrn3 stabilizes the monomeric initiation competent Pol I to ...
Michael Pilsl +8 more
doaj +1 more source
Transcriptional Regulation by the Numbers 1: Models [PDF]
arXiv, 2004 The study of gene regulation and expression is often discussed in quantitative terms. In particular, the expression of genes is regularly characterized with respect to how much, how fast, when and where. Whether discussing the level of gene expression in a bacterium or its precise location within a developing embryo, the natural language for these ...
arxiv
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
DNA dependent RNA polymerase from vegetative cells and from spores of B.Subtilis: III. Isolation of a stimulating factor [PDF]
, 1969 Pierre Kerjan, Jekisiel Szulmajster
openalex +1 more source
, 2022 In eukaryotes, the task of RNA synthesis is divided between three RNA polymerases (RNAPs). RNA polymerase I (Pol I) produces ribosomal RNA (rRNA), and Pol III specialises in making short, non-transcribed RNAs, which together constitute the majority of the RNA pool.
openaire +2 more sources
Monoclonal antibody to RNA polymerase I of the silkworm.
Journal of Biological Chemistry, 1983 RNA polymerase I has been purified from the silk glands of the silkworm and antibodies obtained from immunized BALB/C mice. Hybridomas were obtained by fusing spleen cells from the same mice with SP-2/0 cells. One of the cloned hybridomas was injected into mice to produce ascitic fluid.
S Sridhara, S Gowda
openaire +3 more sources
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Cell Reports, 2013 Multisubunit RNA polymerases (msRNAPs) exhibit high sequence and structural homology, especially within their active sites, which is generally thought to result in msRNAP functional conservation.
Olga V. Viktorovskaya +8 more
doaj +1 more source