Results 131 to 140 of about 1,401,767 (284)
Novel Escherichia coli RNA Polymerase Binding Protein Encoded by Bacteriophage T5
Viruses, 2020 The Escherichia coli bacteriophage T5 has three temporal classes of genes (pre-early, early, and late). All three classes are transcribed by host RNA polymerase (RNAP) containing the σ70 promoter specificity subunit.
Evgeny Klimuk +5 more
doaj +1 more source
RNA polymerase motors: dwell time distribution, velocity and dynamical phases [PDF]
, 2009 Polymerization of RNA from a template DNA is carried out by a molecular machine called RNA polymerase (RNAP). It also uses the template as a track on which it moves as a motor utilizing chemical energy input. The time it spends at each successive monomer of DNA is random; we derive the exact distribution of these "dwell times" in our model. The inverse
arxiv +1 more source
FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress [PDF]
, 2019 FUS (fused in sarcoma) plays a key role in several steps of RNA metabolism, and dominant mutations in this protein are associated with neurodegenerative diseases.
Caldecott, Keith W +8 more
core +2 more sources
Characterization of RNA Polymerase I Trigger Loop Mutations [PDF]
, 2021 RNA polymerases are primarily multi-subunit enzymes that synthesize RNAs from template DNA strands. RNA polymerase I (Pol I) is the eukaryotic RNA polymerase that synthesizes the majority of ribosomal RNA (rRNA) for ribosome production. These include the
Ainslie, Collin
core +1 more source
Structure and function of RNA polymerase I subunits [PDF]
, 2010 Geiger, Sebastian
core +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 1984 Rabbit antibodies to RNA polymerase I from a rat hepatoma have been used to localize the enzyme in a variety of cells at the light and electron microscopic level. In interphase cells the immunofluorescence pattern indicated that polymerase I is contained
Ulrich Scheer, Kathleen M. ROSEt
semanticscholar +1 more source
Transient-State Kinetic Analysis of the RNA Polymerase I Nucleotide Incorporation Mechanism [PDF]
, 2015 The diversity of enzymes and the reactions which they catalyze is enormous. Careful study of enzymatic reaction mechanisms has taught us a great deal about chemical reactivity and has given us insight into the chemical and physical basis of life.
Appling, Francis Dean
core +1 more source
UBF-binding site arrays form pseudo-NORs and sequester the RNA polymerase I transcription machinery.
Genes & Development, 2005 Human ribosomal genes (rDNA) are located in nucleolar organizer regions (NORs) on the short arms of acrocentric chromosomes. Metaphase NORs that were transcriptionally active in the previous cell cycle appear as prominent chromosomal features termed ...
C. Mais +4 more
semanticscholar +1 more source
Cell Reports, 2018 Summary: Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is ...
Ting Wei +6 more
doaj
hRRN3 is essential in the SL1‐mediated recruitment of RNA Polymerase I to rRNA gene promoters
EMBO Journal, 2001 A crucial step in transcription is the recruitment of RNA polymerase to promoters. In the transcription of human rRNA genes by RNA Polymerase I (Pol I), transcription factor SL1 has a role as the essential core promoter binding factor.
G. Miller +5 more
semanticscholar +1 more source