DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1α gene locus [PDF]
, 2009 Laura Baranello +4 more
openalex +1 more source
E. coli 6S RNA complexed to RNA polymerase maintains product RNA synthesis at low cellular ATP levels by initiation with non-canonical initiator nucleotides [PDF]
, 2022 Christopher David Bonar +4 more
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin +12 more
wiley +1 more source
In vivo diversification of target genomic sites using processive T7 RNA polymerase-base deaminase fusions blocked by RNA-guided dCas9 [PDF]
, 2019 Beatriz Álvarez +3 more
openalex +1 more source
Regulation of RNA Polymerase I Stability and Function. [PDF]
Cancers (Basel), 2022 Pitts S, Laiho M.
europepmc +1 more source
Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen +18 more
wiley +1 more source
RNA polymerase II-binding aptamers in human ACRO1 satellites disrupt transcription in cis
, 2020 Jennifer L. Boots +10 more
openalex +1 more source
PAF49: An RNA Polymerase I subunit essential for rDNA transcription and stabilization of PAF53. [PDF]
J Biol Chem, 2023 McNamar R +6 more
europepmc +1 more source
Arthritis Care &Research, EarlyView.Objective In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently, and at the point of care. Methods We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of the trajectory of a ...
Ji Soo Kim +18 more
wiley +1 more source