Results 11 to 20 of about 1,002,934 (332)
Transcription termination by RNA polymerase I
, 2023 ABSTRACTTranscription elongation is stochastic and driven by a Brownian ratchet mechanism, making it subject to changes in velocity. However, on regions occupied by multiple polymerases, notably the rDNA, DNA rotation plus torsion constrain polymerase molecules to proceed at the same rate generating “torsional entrainment”.
Tomasz W. Turowski +3 more
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Structure of the initiation-competent RNA polymerase I and its implication for transcription [PDF]
Nature Communications, 2016 Eukaryotic RNA polymerase I (Pol I) is responsible for the transcription of rRNA genes. Here the authors determine the cryo-EM structure of the Pol I-Rrn3 complex, providing insight into how Rrn3 stabilizes the monomeric initiation competent Pol I to ...
Michael Pilsl +8 more
doaj +2 more sources
RNA Polymerase I Dysfunction Underlying Craniofacial Syndromes: Integrated Genetic Analysis Reveals Parallels to 22q11.2 Deletion Syndrome [PDF]
Genes (Basel)Spencer Silvey +2 more
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Functional Architecture of RNA Polymerase I [PDF]
Cell, 2007 Synthesis of ribosomal RNA (rRNA) by RNA polymerase (Pol) I is the first step in ribosome biogenesis and a regulatory switch in eukaryotic cell growth. Here we report the 12 A cryo-electron microscopic structure for the complete 14-subunit yeast Pol I, a homology model for the core enzyme, and the crystal structure of the subcomplex A14/43.
Kuhn, C. +9 more
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Regulation of Eukaryotic RNAPs Activities by Phosphorylation
Frontiers in Molecular Biosciences, 2021 Evolutionarily conserved kinases and phosphatases regulate RNA polymerase II (RNAPII) transcript synthesis by modifying the phosphorylation status of the carboxyl-terminal domain (CTD) of Rpb1, the largest subunit of RNAPII.
Araceli González-Jiménez +5 more
doaj +1 more source
Direct Characterization of Transcription Elongation by RNA Polymerase I. [PDF]
PLoS ONE, 2016 RNA polymerase I (Pol I) transcribes ribosomal DNA and is responsible for more than 60% of transcription in a growing cell. Despite this fundamental role that directly impacts cell growth and proliferation, the kinetics of transcription by Pol I are ...
Suleyman Ucuncuoglu +5 more
doaj +1 more source
Molecular Evolution of RNA-Dependent RNA Polymerase Region in Norovirus Genogroup I
Viruses, 2023 Norovirus is the leading viral agent of gastroenteritis in humans. RNA-dependent RNA polymerase (RdRp) is essential in the replication of norovirus RNA. Here, we present a comprehensive evolutionary analysis of the norovirus GI RdRp gene.
Nan Zhou +4 more
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The RNA polymerase I transcription machinery [PDF]
Biochemical Society Symposia, 2006 The rRNAs constitute the catalytic and structural components of the ribosome, the protein synthesis machinery of cells. The level of rRNA synthesis, mediated by Pol I (RNA polymerase I), therefore has a major impact on the life and destiny of a cell.
Russell, Jackie +1 more
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Characterization of RNA polymerases from Rous sarcoma virus-induced mouse ascites sarcoma cells. [PDF]
, 1979 RNA polymerase was extracted from the Schmidt-Ruppin strain of Rous sarcoma virus (SR-RSV)-induced C3H/He mouse ascites sarcoma cells (SR-C3H). RNA polymerase was separated into RNA polymerases I and II by DEAE-Sephadex chromatography.
Misumi, Hiromasa, Oda, Takuzo
core +1 more source
RNA Polymerase I Holoenzyme-Promoter Interactions [PDF]
Journal of Biological Chemistry, 2000 In plants and animals, RNA polymerase I (pol I) can be purified in a form that is self-sufficient for accurate rRNA gene promoter-dependent transcription and that has biochemical properties suggestive of a single complex, or holoenzyme. In this study, we examined the promoter binding properties of a highly purified Brassica pol I holoenzyme activity ...
J, Saez-Vasquez, C S, Pikaard
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