Results 261 to 270 of about 1,401,767 (284)

Transcription by RNA polymerase I

Frontiers in Bioscience, 1998
The genes that code for 45S rRNA, the precursor of 18S, 5.8S and 28S rRNA, are transcribed by RNA polymerase I. In many eukaryotes the genes are arranged as tandem repeats in discrete chromosomal clusters. rDNA transcription and rRNA processing occur in the nucleolus. In vertebrates, at least two factors, SL-1 and UBF, specific for transcription by RNA
Katherine M. Hannan, Ross D. Hannan, Lawrence I. Rothblum   +2 more
openaire   +2 more sources

Flaviviridae polymerase and RNA replication

Journal of Viral Hepatitis, 1999
Sequence motifs within the non‐structural protein NS5 or NS5B of the members of the family Flaviviridae suggest that this protein is the RNA‐dependent RNA polymerase. This protein has now been expressed in various in vitro systems and used in polymerase assays.
P. Thompson, A. Bartholomeusz
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Epigenetic silencing of RNA polymerase I transcription [PDF]

Nature Reviews Molecular Cell Biology, 2003
The genes that encode ribosomal RNA exist in two distinct types of chromatin--an 'open' conformation that is permissive to transcription and a 'closed' conformation that is transcriptionally refractive. Recent studies have provided insights into the molecular mechanisms that silence either entire nucleolus organizer regions (NORs) in genetic hybrids or
Craig S. Pikaard, Ingrid Grummt
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A model for transcription termination by RNA polymerase I [PDF]

Cell, 1994
The transcription termination site for yeast RNA polymerase I requires not only an 11 bp binding site for Reb1p, but also about 46 bp of 5' flanking sequence. We propose that Reb1p bound to its site is part of a pause element, while the 5' flanking sequence contains a release element.
Walter H. Lang, Jonathan R. Warner, Bernice E. Morrow, Ronald H. Reeder, Qida Ju   +4 more
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The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer.

Annual Review of Pharmacology and Toxicology, 2010
The RNA polymerase I (Pol I) transcription machinery in the nucleolus is the key convergence point that collects and integrates a vast array of information from cellular signaling cascades to regulate ribosome production that in turn guides cell growth ...
D. Drygin, W. Rice, I. Grummt
semanticscholar   +1 more source

RNA Polymerases I and III in development and disease

Seminars in Cell & Developmental Biology, 2023
Ribosomes are macromolecular machines that are globally required for the translation of all proteins in all cells. Ribosome biogenesis, which is essential for cell growth, proliferation and survival, commences with transcription of a variety of RNAs by RNA Polymerases I and III.
Kristin En, Watt, Julia, Macintosh, Geneviève, Bernard, Paul A, Trainor   +3 more
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Phosphorylation of RNA polymerases: specific association of protein kinase NIl with RNA polymerase I

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1983
The activities of the three DNA-dependent RNA polymerases from a rapidly growing rat tumour, Morris hepatoma 3924 A, and from rat liver were examined. The activity of RNA polymerase I was higher in the tumour than in the liver. The enhanced capacity for RNA synthesis was a result of a higher concentration of polymerase I in the tumour as ...
Samson T. Jacob, Dean A. Stetler, Kathleen M. Rose   +2 more
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Processing and termination of RNA polymerase I transcripts

BioEssays, 1987
AbstractElectron micrographs of active ribosomal genes from many species show a similar picture in which gene regions covered with nascent transcripts alternate with apparently non‐transcribed spacers. Since the gradients of visible nascent transcripts stop near the 3′ end of the 28S sequence it has often been assumed that transcription by RNA ...
Brian McStay, Ronald H. Reeder, Paul Labhart   +2 more
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A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013
RNA polymerase I and III are responsible for the bulk of nuclear transcription in actively growing cells and their activity impacts the cellular biosynthetic capacity. As a consequence, RNA polymerase I and III deregulation has been directly linked to cancer development.
openaire   +3 more sources

Species specificity of transcription by RNA polymerase I

Current Opinion in Genetics & Development, 1995
An unusual property of ribosomal gene transcription is its marked species specificity. This results from distinct promoter-recognition properties of the RNA polymerase I transcription apparatus. The purification and functional characterization of TIF-IB/SL1, a promoter-recognition factor containing the TATA-binding protein, as well as the recent ...
Ingrid Grummt, Jutta Heix
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