Results 31 to 40 of about 950,582 (330)
Identification of the RNA polymerase I-RNA interactome
Nucleic Acids Research, 2018 Ribosome biogenesis is a complex process orchestrated by a host of ribosome assembly factors. Although it is known that many of the proteins involved in this process have RNA binding activity, the full repertoire of proteins that interact with the precursor ribosomal RNA is currently unknown.
Piñeiro, David +8 more
openaire +3 more sources
TFIIH is an elongation factor of RNA polymerase I [PDF]
Nucleic Acids Research, 2011 TFIIH is a multisubunit factor essential for transcription initiation and promoter escape of RNA polymerase II and for the opening of damaged DNA double strands in nucleotide excision repair (NER). In this study, we have analyzed at which step of the transcription cycle TFIIH is essential for transcription by RNA polymerase I. We demonstrate that TFIIH
Sebastian Iben +5 more
openaire +3 more sources
The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation. [PDF]
PLoS ONE, 2013 The promoters of poised rRNA genes (rDNA) are marked by both euchromatic and heterochromatic histone modifications and are associated with two transcription factors, UBF and SL1 that nucleate transcription complex formation.
Meili Shen +9 more
doaj +1 more source
A 212-nt long RNA structure in the Tobacco necrosis virus-D RNA genome is resistant to Xrn degradation [PDF]
, 2019 Plus-strand RNA viruses can accumulate viral RNA degradation products during infections. Some of these decay intermediates are generated by the cytosolic 5′-to-3′ exoribonuclease Xrn1 (mammals and yeast) or Xrn4 (plants) and are formed when the enzyme ...
Chaminda, Gunawardene D. +2 more
core +1 more source
Autoantibody to RNA polymerase I in scleroderma sera. [PDF]
Journal of Clinical Investigation, 1987 Autoantibodies to components of the nucleolus are a unique serological feature of patients with scleroderma. There are autoantibodies of several specificities; one type produces a speckled pattern of nucleolar staining in immunofluorescence. In actinomycin D and 5,6-dichloro-beta-D-ribofuranosylbenzimidazole-treated Vero cells, staining was restricted ...
Reimer, Georg +3 more
openaire +4 more sources
Identification of DHX33 as a mediator of rRNA synthesis and cell growth [PDF]
, 2011 In this report, we employed a lentiviral RNA interference screen to discover nucleolar DEAD/DEAH-box helicases involved in RNA polymerase I (Pol I)-mediated transcriptional activity.
Forys, Jason T +4 more
core +3 more sources
Zinc'ing down RNA polymerase I [PDF]
Transcription, 2013 Most RNA polymerases contain zinc, yet the precise function of zinc and its influence of polymerases stability are unknown. A recent study provides evidence that zinc levels control the stability of RNA polymerase I in vivo and that the enzyme might serve as a zinc reservoir for other proteins.
openaire +5 more sources
Efficient termination of transcription by RNA polymerase I requires the 5 ' exonuclease Rat1 in yeast [PDF]
, 2008 During transcription termination by RNA polymerase II on protein-coding genes, the nuclear 5′ exonuclease Rat1/Xrn2 degrades the nascent transcript downstream from the polyadenylation site and “torpedoes” the polymerase.
El Hage, Aziz +3 more
core +2 more sources
Loss of Proteostasis Is a Pathomechanism in Cockayne Syndrome
Cell Reports, 2018 Summary: Retarded growth and neurodegeneration are hallmarks of the premature aging disease Cockayne syndrome (CS). Cockayne syndrome proteins take part in the key step of ribosomal biogenesis, transcription of RNA polymerase I.
Marius Costel Alupei +11 more
doaj +1 more source
Cellular sensitivity to UV-irradiation is mediated by RNA polymerase I transcription. [PDF]
PLoS ONE, 2017 The nucleolus has long been considered to be a pure ribosome factory. However, over the last two decades it became clear that the nucleolus is involved in numerous other functions besides ribosome biogenesis. Our experiments indicate that the activity of
Robin Assfalg +7 more
doaj +1 more source