Results 41 to 50 of about 1,002,934 (332)

Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. [PDF]

, 2010
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes.
Alekseyenko, Artyom A, Bishop, Eric P, Canfield, Theresa K, Elgin, Sarah CR, Ernst, Jason, Gorchakov, Andrey A, Gu, Tingting, Jung, Youngsook L, Karpen, Gary H, Kellis, Manolis, Kharchenko, Peter V, Kuroda, Mitzi I, Larschan, Erica, Linder-Basso, Daniela, Luquette, Lovelace J, MacAlpine, David M, Minoda, Aki, Park, Peter J, Park, Richard W, Pirrotta, Vincenzo, Plachetka, Annette, Riddle, Nicole C, Sabo, Peter J, Sandstrom, Richard, Schwartz, Yuri B, Shanower, Gregory, Stamatoyannopoulos, John A, Thurman, Robert E, Tolstorukov, Michael Y, Xi, Ruibin   +29 more
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Cytoplasmic RNA Polymerase in Escherichia coli [PDF]

Journal of Bacteriology, 2001
ABSTRACT To obtain an estimate for the concentration of free functional RNA polymerase in the bacterial cytoplasm, the content of RNA polymerase β and β′ subunits in DNA-free minicells from the minicell-producing Escherichia coli strain χ925 was determined.
N, Shepherd, P, Dennis, H, Bremer
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Identification of the RNA polymerase I-RNA interactome

Nucleic Acids Research, 2018
Ribosome biogenesis is a complex process orchestrated by a host of ribosome assembly factors. Although it is known that many of the proteins involved in this process have RNA binding activity, the full repertoire of proteins that interact with the precursor ribosomal RNA is currently unknown.
Piñeiro, David, Stoneley, Mark, Ramakrishna, Manasa, Alexandrova, Jana, Dezi, Veronica, Juke-Jones, Rebekha, Lilley, Kathryn S, Cain, Kelvin, Willis, Anne E   +8 more
openaire   +2 more sources

RNA polymerase I structure and transcription regulation [PDF]

Nature, 2013
Transcription of ribosomal RNA by RNA polymerase (Pol) I initiates ribosome biogenesis and regulates eukaryotic cell growth. The crystal structure of Pol I from the yeast Saccharomyces cerevisiae at 2.8 Å resolution reveals all 14 subunits of the 590-kilodalton enzyme, and shows differences to Pol II.
Engel, C., Sainsbury, S., Cheung, A.C., Kostrewa, D., Cramer, P.   +4 more
openaire   +5 more sources

Structural mechanism of ATP-independent transcription initiation by RNA polymerase I

eLife, 2017
Transcription initiation by RNA Polymerase I (Pol I) depends on the Core Factor (CF) complex to recognize the upstream promoter and assemble into a Pre-Initiation Complex (PIC). Here, we solve a structure of Saccharomyces cerevisiae Pol I-CF-DNA to 3.8 Å
Yan Han, Chunli Yan, Thi Hoang Duong Nguyen, Ashleigh J Jackobel, Ivaylo Ivanov, Bruce A Knutson, Yuan He   +6 more
doaj   +1 more source

Cell volume homeostatically controls the rDNA repeat copy number and rRNA synthesis rate in yeast.

PLoS Genetics, 2021
The adjustment of transcription and translation rates to the changing needs of cells is of utmost importance for their fitness and survival. We have previously shown that the global transcription rate for RNA polymerase II in budding yeast Saccharomyces ...
José E Pérez-Ortín, Adriana Mena, Marina Barba-Aliaga, Abhyudai Singh, Sebastián Chávez, José García-Martínez   +5 more
doaj   +1 more source

Modulation of Host Immunity by Human Respiratory Syncytial Virus Virulence Factors: A Synergic Inhibition of Both Innate and Adaptive Immunity [PDF]

, 2017
Indexación: Web of Science; Scopus.The Human Respiratory Syncytial Virus (hRSV) is a major cause of acute lower respiratory tract infections (ARTIs) and high rates of hospitalizations in children and in the elderly worldwide.
Alexis M. Kalergis, Alexis M. Kalergis, Claudia A. Riedel, Emma Rey-Jurado, Gisela Canedo-Marroquín, Juan M. Saavedra, Margarita K. Lay, Margarita K. Lay, Orlando Acevedo-Acevedo, Susan M. Bueno   +9 more
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Molecular Structures of Transcribing RNA Polymerase I [PDF]

Molecular Cell, 2016
RNA polymerase I (Pol I) is a 14-subunit enzyme that solely synthesizes pre-ribosomal RNA. Recently, the crystal structure of apo Pol I gave unprecedented insight into its molecular architecture. Here, we present three cryo-EM structures of elongating Pol I, two at 4.0 Å and one at 4.6 Å resolution, and a Pol I open complex at 3.8 Å resolution.
Lucas Tafur, Yashar Sadian, Niklas A. Hoffmann, Arjen J. Jakobi, Rene Wetzel, Wim J.H. Hagen, Carsten Sachse, Christoph W. Müller   +7 more
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Small-Molecule Targeting of RNA Polymerase I Activates a Conserved Transcription Elongation Checkpoint

Cell Reports, 2018
Summary: Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is ...
Ting Wei, Saman M. Najmi, Hester Liu, Karita Peltonen, Alena Kucerova, David A. Schneider, Marikki Laiho   +6 more
doaj   +1 more source

Structural Basis of RNA Polymerase I Transcription Initiation [PDF]

Cell, 2017
Transcription initiation at the ribosomal RNA promoter requires RNA polymerase (Pol) I and the initiation factors Rrn3 and core factor (CF). Here, we combine X-ray crystallography and cryo-electron microscopy (cryo-EM) to obtain a molecular model for basal Pol I initiation.
Engel, Christoph, Gubbey, Tobias, Neyer, Simon, Sainsbury, Sarah, Oberthuer, Christiane, Baejen, Carlo, Bernecky, Carrie, Cramer, Patrick   +7 more
openaire   +4 more sources