Results 41 to 50 of about 950,582 (330)
Specific Features of RNA Polymerases I and III: Structure and Assembly
Frontiers in Molecular Biosciences, 2021 RNA polymerase I (RNAPI) and RNAPIII are multi-heterogenic protein complexes that specialize in the transcription of highly abundant non-coding RNAs, such as ribosomal RNA (rRNA) and transfer RNA (tRNA).
Tomasz W. Turowski +2 more
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Termination of transcription by yeast RNA polymerase I [PDF]
Nucleic Acids Research, 1989 Analysis of the termination of transcription by yeast RNA polymerase I (Pol I) using in vitro run-on experiments in both isolated nuclei and permeabilized cells demonstrated that Pol I does not traverse the whole intergenic spacer separating consecutive 37S operons, but terminates transcription before reaching the 5S rRNA gene, that is within NTS 1. In
I. J. De Wijs +6 more
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RNA polymerase I–Rrn3 complex at 4.8 Å resolution
Nature Communications, 2016 RNA polymerase I is the central enzyme that synthesizes ribosomal RNA in eukaryotic cells, and its regulation underlies cell growth. Here the authors present a high-resolution cryo-EM structure of the Pol I-Rrn3 complex that explains how Rrn3 ...
Christoph Engel +2 more
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Viruses, 2019 Flaviviruses, most of which are emerging and re-emerging human pathogens and significant public health concerns worldwide, are positive-sense RNA viruses. Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which
YanPing Duan +17 more
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Structural mechanism of ATP-independent transcription initiation by RNA polymerase I
eLife, 2017 Transcription initiation by RNA Polymerase I (Pol I) depends on the Core Factor (CF) complex to recognize the upstream promoter and assemble into a Pre-Initiation Complex (PIC). Here, we solve a structure of Saccharomyces cerevisiae Pol I-CF-DNA to 3.8 Å
Yan Han +6 more
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Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. [PDF]
, 2010 Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes.
Alekseyenko, Artyom A +29 more
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RNA Polymerase I Holoenzyme-Promoter Interactions [PDF]
Journal of Biological Chemistry, 2000 In plants and animals, RNA polymerase I (pol I) can be purified in a form that is self-sufficient for accurate rRNA gene promoter-dependent transcription and that has biochemical properties suggestive of a single complex, or holoenzyme. In this study, we examined the promoter binding properties of a highly purified Brassica pol I holoenzyme activity ...
Craig S. Pikaard, Julio Sáez-Vásquez
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Cell volume homeostatically controls the rDNA repeat copy number and rRNA synthesis rate in yeast.
PLoS Genetics, 2021 The adjustment of transcription and translation rates to the changing needs of cells is of utmost importance for their fitness and survival. We have previously shown that the global transcription rate for RNA polymerase II in budding yeast Saccharomyces ...
José E Pérez-Ortín +5 more
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TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycle [PDF]
, 2016 Transcription is an intrinsically dynamic process and requires the coordinated interplay of RNA polymerases (RNAPs) with nucleic acids and transcription factors.
Gietl, Andreas +5 more
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Cell Reports, 2018 Summary: Inhibition of RNA polymerase I (Pol I) is a promising strategy for modern cancer therapy. BMH-21 is a first-in-class small molecule that inhibits Pol I transcription and induces degradation of the enzyme, but how this exceptional response is ...
Ting Wei +6 more
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