Results 61 to 70 of about 807,500 (308)

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Estrogen-induced modification of uterine RNA polymerase activity depends on localization of the estrogen receptor [PDF]

Archives of Biological Sciences, 2007
The aim of this study was to examine the effects of estradiol (E2) on activity of RNA polymerase I and RNA polymerase II in uterine nuclei of ovariectomized (OVX) female rats.
Žakula Zorica, Isenović Esma R., Stojiljković Mojca, Korićanac G., Tepavčević Snežana, Ribarac-Stepić Nevena   +5 more
doaj   +1 more source

Fusarium oxysporum Associated with Fusarium Wilt on Pennisetum sinese in China

Pathogens, 2022
Pennisetum sinese, a versatile and adaptable plant, plays an essential role in phytoremediation, soil reclamation, and fodder production. From 2018 to 2021, the occurrence of Fusarium wilt, with symptoms of foliar blight and internal discoloration of the
Jiaqi Zheng, Liyao Wang, Wenchao Hou, Yuzhu Han   +3 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

CTCF regulates the local epigenetic state of ribosomal DNA repeats

Epigenetics & Chromatin, 2010
Background CCCTC binding factor (CTCF) is a highly conserved zinc finger protein, which is involved in chromatin organization, local histone modifications, and RNA polymerase II-mediated gene transcription.
van de Nobelen Suzanne, Rosa-Garrido Manuel, Leers Joerg, Heath Helen, Soochit Widia, Joosen Linda, Jonkers Iris, Demmers Jeroen, van der Reijden Michael, Torrano Verónica, Grosveld Frank, Delgado M Dolores, Renkawitz Rainer, Galjart Niels, Sleutels Frank   +14 more
doaj   +1 more source

Model of Transcriptional Activation by MarA in Escherichia coli [PDF]

, 2009
We have developed a mathematical model of transcriptional activation by MarA in Escherichia coli, and used the model to analyze measurements of MarA-dependent activity of the marRAB, sodA, and micF promoters in mar-rob- cells. The model rationalizes an unexpected poor correlation between the mid-point of in vivo promoter activity profiles and in vitro ...
arxiv   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Targeting the RNA Polymerase I Transcription for Cancer Therapy Comes of Age

Cells, 2020
Transcription of the ribosomal RNA genes (rDNA) that encode the three largest ribosomal RNAs (rRNA), is mediated by RNA Polymerase I (Pol I) and is a key regulatory step for ribosomal biogenesis.
Rita Ferreira, John S. Schneekloth, Konstantin I. Panov, Katherine M. Hannan, Ross D. Hannan   +4 more
doaj   +1 more source

Interchangeable RNA polymerase I and II enhancers. [PDF]

Proceedings of the National Academy of Sciences, 1990
The RNA polymerase I (pol I) enhancer of Saccharomyces cerevisiae contains at least three elements commonly associated with RNA polymerase II (pol II) enhancers, binding sites for the transcriptional activators general regulatory factor 2 and autonomously replicating sequence-binding factor I, and a thymidine-rich element.
Neal F. Lue, Roger D. Kornberg, Yahli Lorch   +2 more
openaire   +3 more sources

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source