Results 121 to 130 of about 946,604 (388)

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Requirements for RNA polymerase II preinitiation complex formation in vivo

eLife, 2019
Transcription by RNA polymerase II requires assembly of a preinitiation complex (PIC) composed of general transcription factors (GTFs) bound at the promoter.
Natalia Petrenko, Yi Jin, Liguo Dong, Koon Ho Wong, Kevin Struhl   +4 more
doaj   +1 more source

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1. [PDF]

, 2018
Tight binding of Gdown1 represses RNA polymerase II (Pol II) function in a manner that is reversed by Mediator, but the structural basis of these processes is unclear.
A Leitner, A Rohou, A Sali, AL Gnatt, Andrej Sali, BL Allen, Brian T. Chait, C Bernecky, C Plaschka, C Suloway, D Kostrewa, D Russel, EF Pettersen, F Yue, Francisco J. Asturias, G Pan, GC Lander, H Ueda, J Eichner, J Fernandez-Martinez, J Sun, L Fagerberg, M Jishage, MA Cevher, Miki Jishage, P Emsley, PB Rosenthal, PV Afonine, R Algret, RG Roeder, Robert G. Roeder, S Grunberg, S Malik, S Malik, S Malik, S Malik, S Sainsbury, S Sainsbury, S Tan, Sai J. Ganesan, SH Scheres, SH Scheres, T Kanesaki, VB Chen, W Muhlbacher, Wei-Yi Chen, X Hu, X Li, XC Bai, Xiaodi Yu, Y He, Y He, Y Shi, Y Shi, Yi Shi, YM Wu, ZA Chen   +56 more
core   +2 more sources

Phosphorylation and functions of the RNA polymerase II CTD.

Genes & Development, 2006
The C-terminal repeat domain (CTD), an unusual extension appended to the C terminus of the largest subunit of RNA polymerase II, serves as a flexible binding scaffold for numerous nuclear factors; which factors bind is determined by the phosphorylation ...
H. Phatnani, A. Greenleaf
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase*

Journal of Biological Chemistry, 1996
The entry of RNA polymerase II into a productive mode of elongation is controlled, in part, by the postinitiation activity of positive transcription elongation factor b (P-TEFb) (Marshall, N. F., and Price, D. H. (1995) J. Biol. Chem.
N. Marshall, Jun Peng, Z. Xie, D. Price
semanticscholar   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Azotobacter vinelandii RNA polymerase. II - Effect of ribonuclease on polymerase activity [PDF]

Ribonuclease effect on polymerase activity during ribonucleic acid synthesis ...
Krakow, J. S.
core   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Functional interaction of human Ssu72 with RNA polymerase II complexes.

PLoS ONE, 2019
Phosphorylation of the C-terminal domain (CTD) of the large subunit of human RNA polymerase II (Pol II) is regulated during the transcription cycle by the combined action of specific kinases and phosphatases. Pol II enters into the preinitiation complex (
Benjamin M Spector, Michael E Turek, David H Price   +2 more
doaj   +1 more source