Results 141 to 150 of about 946,604 (388)
Rsp5 promotes Gene Activation mediated by 9aaTAD Transcription Factors Oaf1 and Gal4 [PDF]
, 2009 Nine-amino-acid transactivation domain, 9aaTAD, defines a large superfamily of yeast and mammals transcription factors. The transactivation of the 9aaTAD has been addressed to multiple general co-activators TAF9, MED15, CBP and p300.
Joachim Lipp +2 more
core +1 more source
Encephalomyocarditis Virus Infection of Mouse Plasmacytoma Cells II. Effect on Host RNA Synthesis and RNA Polymerases [PDF]
, 1974 Lawrence B. Schwartz +3 more
openalex +1 more source
Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity
Genes & Development, 2018 In this study, Eaton et al. use a new gene-editing approach to delineate the mechanism by which RNA polymerase II terminates. They generated human cell lines from which the 5′-to-3′ exoribonuclease Xrn2 or the poly(A) signal endoribonuclease CPSF73 can ...
Joshua D. Eaton +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
RNA polymerase II from mutant and wild type strains of Caenorhabditis elegans [PDF]
, 1985 Includes vita.Studies of transcription in Caenorhabditis elegans, a model organism for the study of developmental genetics, should contribute to an understanding of the developmental process in metazoans.
Sanford, Thomas Robert
core
Structural Relationships Among the Multiple Forms of DNA-Dependent RNA Polymerase II from Cultured Parsley Cells [PDF]
, 1978 Gerhard Link +2 more
openalex +1 more source
The Role of TAFs in RNA Polymerase II Transcription [PDF]
Cell, 1998 While these new results are not definitive, they neatly frame some important questions that need to be addressed regarding the role of TAFs in TFIID and SAGA function and suggest experimental approaches to address these questions.Is TFIID Generally Required for Pol II Transcription?
openaire +3 more sources
Paf1C regulates RNA polymerase II progression by modulating elongation rate
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The factors that regulate RNA polymerase II (Pol II) elongation rate and processivity are poorly understood. Here, we show that the Paf1 complex (Paf1C) modulates Pol II elongation rate, and loss of Paf1 results in accumulation of Ser5P in ...
Liming Hou +7 more
semanticscholar +1 more source
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Nature CommunicationsThe Rat1 5’-3’ exoribonuclease together with its partner Rai1 have important roles in Saccharomyces cerevisiae RNA polymerase II transcription termination. Rtt103 copurifies with Rat1-Rai1 in S.
Hsu-Feng Chu, Liang Tong
doaj +1 more source