Results 311 to 320 of about 821,958 (335)
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Dephosphorylating RNA polymerase II
Science, 2020Transcription Transcription in metazoans requires coordination of multiple factors to control the progression of polymerases and the integrity of their RNA products. Zheng et al. identified a new dual-enzyme complex called INTAC, which is composed of protein phosphatase 2A (PP2A) core enzyme and the multisubunit RNA endonuclease Integrator.
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RNA polymerase II elongation through chromatin
Nature, 2000The machinery that transcribes protein-coding genes in eukaryotic cells must contend with repressive chromatin structures in order to find its target DNA sequences. Diverse arrays of proteins modify the structure of chromatin at gene promoters to help transcriptional regulatory proteins access their DNA recognition sites. The way in which disruption of
G, Orphanides, D, Reinberg
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Transcript Elongation by RNA Polymerase II
Annual Review of Biochemistry, 2010Until recently, it was generally assumed that essentially all regulation of transcription takes place via regions adjacent to the coding region of a gene—namely promoters and enhancers—and that, after recruitment to the promoter, the polymerase simply behaves like a machine, quickly “reading the gene.” However, over the past decade a revolution in ...
Selth, L., Sigurdsson, S., Svejstrup, J.
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RNA polymerase II transcription cycles
Current Opinion in Genetics & Development, 1993RNA polymerase II interacts with transcription factors to initiate the synthesis of mRNA. These interactions are cyclic, involving multiple RNA polymerase subunits and general transcription factors. Phosphorylation of the RNA polymerase II carboxyl-terminal domain may regulate these interactions.
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Journal of Molecular Biology, 2000
Bacterial RNA polymerase and eukaryotic RNA polymerase II exhibit striking structural similarities, including similarities in overall structure, relative positions of subunits, relative positions of functional determinants, and structures and folding topologies of subunits.
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Bacterial RNA polymerase and eukaryotic RNA polymerase II exhibit striking structural similarities, including similarities in overall structure, relative positions of subunits, relative positions of functional determinants, and structures and folding topologies of subunits.
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The RNA Polymerase II Core Promoter
Annual Review of Biochemistry, 2003▪ Abstract The events leading to transcription of eukaryotic protein-coding genes culminate in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which can extend ∼35 bp upstream and/or downstream of this site, plays a central role in regulating initiation.
Stephen T, Smale, James T, Kadonaga
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The Mediator of RNA polymerase II
Chromosoma, 2005Mediator (TRAP/ARC/PC2) is a large (22-28 subunit) protein complex that binds RNA polymerase II and controls transcription from class II genes. The evolutionarily conserved core of Mediator is found in all eukaryotes. It binds RNA polymerase II and is probably critical for basal transcription but it also mediates activation and repression of ...
Erik, Blazek +2 more
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2013
Structures of yeast RNA polymerase II, alone and in the act of transcription with associated DNA and RNA, have been determined to near-atomic resolution. The structures illuminate the basis for the fidelity of transcription, for translocation on the DNA template, and for release of the product RNA.
David A. Bushnell, Roger D. Kornberg
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Structures of yeast RNA polymerase II, alone and in the act of transcription with associated DNA and RNA, have been determined to near-atomic resolution. The structures illuminate the basis for the fidelity of transcription, for translocation on the DNA template, and for release of the product RNA.
David A. Bushnell, Roger D. Kornberg
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Advances in RNA polymerase II transcription
Current Biology, 1992Multiple protein factors are necessary to mediate transcription by RNA polymerase II. Recently, a number of advances have been made in our understanding of how general transcription factors collectively modulate basal transcription in the context of different promoter environments and how this process is activated and repressed by accessory components.
L, Zawel, D, Reinberg
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Promoter escape by RNA polymerase II
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002Transcription of protein-coding genes is one of the most fundamental processes that underlies all life and is a primary mechanism of biological regulation. In eukaryotic cells, transcription depends on the formation of a complex at the promoter region of the gene that minimally includes RNA polymerase II and several auxiliary proteins known as the ...
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