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Control of elongation by RNA polymerase II
Trends in Biochemical Sciences, 2000The elongation stage of eukaryotic mRNA synthesis can be regulated by transcription factors that interact directly with the RNA polymerase II (pol II) elongation complex and by activities that modulate the structure of its chromatin template. Recent studies have revealed new elongation factors and have implicated the general initiation factors TFIIE ...
Arik Dvir +3 more
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Transcription by RNA Polymerase II
1984Gene expression in eukaryotic cells is often regulated at the level of transcription of the gene (see Darnell, 1982). In order to understand viral growth, the response of cells to external stimuli, and the processes of differentiation and development, it is of importance to understand what controls the initiation of transcription at a gene.
Ulla Hansen, Phillip A. Sharp
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Structural Biology of RNA Polymerase II Transcription: 20 Years On.
Annual Review of Cell and Developmental Biology, 2020Gene transcription by RNA polymerase II (Pol II) is the first step in the expression of the eukaryotic genome and a focal point for cellular regulation during development, differentiation, and responses to the environment.
Sara Osman, P. Cramer
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2013
Structures of yeast RNA polymerase II, alone and in the act of transcription with associated DNA and RNA, have been determined to near-atomic resolution. The structures illuminate the basis for the fidelity of transcription, for translocation on the DNA template, and for release of the product RNA.
David A. Bushnell, Roger D. Kornberg
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Structures of yeast RNA polymerase II, alone and in the act of transcription with associated DNA and RNA, have been determined to near-atomic resolution. The structures illuminate the basis for the fidelity of transcription, for translocation on the DNA template, and for release of the product RNA.
David A. Bushnell, Roger D. Kornberg
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Initiation of transcription by RNA polymerase II
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1989La structure des promoteurs de classe II, les facteurs operant via les elements promoteurs TATA box et le site CAP, les proteines se liant a la RNApolymerase II, la transcription a partir des promoteurs ne contenant pas de sequence TATA et les facteurs specifiques de transcription ont ete decrits dans cette ...
Fred Mermelstein +2 more
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Promoter escape by RNA polymerase II
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2002Transcription of protein-coding genes is one of the most fundamental processes that underlies all life and is a primary mechanism of biological regulation. In eukaryotic cells, transcription depends on the formation of a complex at the promoter region of the gene that minimally includes RNA polymerase II and several auxiliary proteins known as the ...
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Chromatin Remodeling by RNA Polymerase II
Molecular Biology, 2005Tight compaction of eukaryotic DNA in chromatin having several levels of organization results in formation of a structure that is barely accessible to regulatory protein complexes and enzymes such as DNA-and RNA-polymerases. To deal with this intricate chromatin organization, numerous chromatin remodeling mechanisms operating at various levels of ...
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Activation of RNA polymerase II transcription
Current Opinion in Cell Biology, 1999Multiple alternative interactions between activators and co-activators stimulate transcription by RNA polymerase II. In the past two years, multiprotein co-activator complexes have been characterized and their subunits defined. TATA-box binding protein associated factor (TAF) subunits of yeast TFIID were found to be generally required for transcription
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Transcription elongation by RNA polymerase II
Current Opinion in Genetics & Development, 2003The elongation of transcripts by RNA polymerase II (RNAPII) is subject to regulation and requires the services of a host of accessory proteins. Although the biochemical mechanisms underlying elongation and its regulation remain obscure, recent progress sets the stage for rapid advancement in our understanding of this phase of transcription.
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RNA polymerase II transcription cycles
Current Opinion in Genetics & Development, 1993RNA polymerase II interacts with transcription factors to initiate the synthesis of mRNA. These interactions are cyclic, involving multiple RNA polymerase subunits and general transcription factors. Phosphorylation of the RNA polymerase II carboxyl-terminal domain may regulate these interactions.
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