Results 81 to 90 of about 991,885 (339)

Phosphorylation and functions of the RNA polymerase II CTD.

Genes & Development, 2006
The C-terminal repeat domain (CTD), an unusual extension appended to the C terminus of the largest subunit of RNA polymerase II, serves as a flexible binding scaffold for numerous nuclear factors; which factors bind is determined by the phosphorylation ...
H. Phatnani, A. Greenleaf
semanticscholar   +1 more source

Mediator Architecture and RNA Polymerase II Interaction

Journal of Molecular Biology, 2016
Integrated structural biology recently elucidated the architecture of Mediator and its position on RNA polymerase II. Here we summarize these achievements and list open questions on Mediator structure and mechanism.
Clemens Plaschka, Kayo Nozawa, Patrick Cramer   +2 more
openaire   +5 more sources

Azotobacter vinelandii RNA polymerase. II - Effect of ribonuclease on polymerase activity [PDF]

Ribonuclease effect on polymerase activity during ribonucleic acid synthesis ...
Krakow, J. S.
core   +1 more source

The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. [PDF]

, 2019
Transcriptional regulation in eukaryotes occurs at promoter-proximal regions wherein transcriptionally engaged RNA polymerase II (Pol II) pauses before proceeding toward productive elongation.
Ablondi, Eileen, Adelman, Karen, Chang, Andrew, Choi, Jee-Eun, Etchegaray, Jean-Pierre, Ferrer, Christina, Goren, Alon, Henriques, Telmo, Ji, Fei, Li, Catherine, Mostoslavsky, Raul, Nakadai, Tomoyoshi, Nechaev, Sergei, Ramaswamy, Sridhar, Roeder, Robert G, Ross, Kenneth N, Sadreyev, Ruslan I, Samarakkody, Ann, Van Rechem, Capucine, Whetstine, Johnathan R, Zhong, Lei   +20 more
core   +1 more source

Evolution of the RNA polymerase II C-terminal domain [PDF]

, 2002
In recent years a great deal of biochemical and genetic research has focused on the C-terminal domain (CTD) of the largest subunit (RPB1) of DNA-dependent RNA polymerase II.
Bienkiewicz, Brett, Burger, Cho, Corden, Corden, Cramer, Evers, Giesecke, Hirose, Hirt, Ho, Huelsenbeck, Jokerst, Kim, Kishino, Lander, Langer, Liao, Logsdon, Maldonado, McCracken, Moreira, Nakajima, Nonet, Nonet, Otero, Puhler, Riedl, Shimodaira, Steinmetz, Stiller, Stiller, Stiller, Stiller, Strimmer, Trigon, Venter, West, Yamamoto, Yuryev, Zehring   +41 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase*

Journal of Biological Chemistry, 1996
The entry of RNA polymerase II into a productive mode of elongation is controlled, in part, by the postinitiation activity of positive transcription elongation factor b (P-TEFb) (Marshall, N. F., and Price, D. H. (1995) J. Biol. Chem.
N. Marshall, Jun Peng, Z. Xie, D. Price
semanticscholar   +1 more source

FUS (fused in sarcoma) is a component of the cellular response to topoisomerase I–induced DNA breakage and transcriptional stress [PDF]

, 2019
FUS (fused in sarcoma) plays a key role in several steps of RNA metabolism, and dominant mutations in this protein are associated with neurodegenerative diseases.
Caldecott, Keith W, Gomez-Herreros, Fernando, Green, Ryan L, Hafezparast, Majid, Hermann, Andreas, Martinez-Macias, Maria Isabel, Moore, Duncan A Q, Naumann, Marcel, Van Damme, Philip   +8 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source