Results 211 to 220 of about 340,586 (247)
A minimal RNA polymerase III transcription system [PDF]
EMBO Journal, 1999 Transcription factor (TF) IIIB recruits RNA polymerase (pol) III for specific initiation of transcription. All three subunits of TFIIIB, TBP, Brf (the TFIIB-related subunit) and B", are required for transcription of supercoiled and linear duplex DNA, but we show here that B" is non-essential on a promoter that has been partly pre-opened by unpairing a ...
George Kassavetis +2 more
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Inhibition of RNA Polymerase III Transcription by BRCA1
Journal of Molecular Biology, 2009RNA polymerase III (RNA pol III) transcribes structural RNAs involved in RNA processing (U6 snRNA) and translation (tRNA), thereby regulating the growth rate of cells. Proper initiation by RNA pol III requires the transcription factor TFIIIB. Gene-external U6 snRNA transcription requires TFIIIB consisting of Bdp1, TBP, and Brf2.
Ingrid, Veras +2 more
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RNA polymerase III transcribes human microRNAs
Nature Structural & Molecular Biology, 2006Prior work demonstrates that mammalian microRNA (miRNA or miR) expression requires RNA polymerase II (Pol II). However, the transcriptional requirements of many miRNAs remain untested. Our genomic analysis of miRNAs in the human chromosome 19 miRNA cluster (C19MC) revealed that they are interspersed among Alu repeats.
Glen M, Borchert +2 more
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Effects of Antibiotics on RNA Polymerase III Transcription
DNA, 1988We investigated the effects of six drugs on an RNA polymerase III in vitro transcription system. Adriamycin, daunorubicin, heparin, rifamycin AF/013, streptolydigin, and streptovaricin all inhibit RNA synthesis from a tRNA gene or the adenovirus 2 (AD2) VA1 RNA gene.
K, Logan, S, Ackerman
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Yeast RNA polymerase III: A zinc metalloenzyme
Biochemical and Biophysical Research Communications, 1977Abstract Atomic absorption spectroscopy has been used to demonstrate that zinc is associated with yeast RNA polymerase III. The enzyme purified by DNA-Sepharose chromatography gives a single predominant protein band in polyacrylamide gel electrophoresis and contains 0.7 gram-atoms of zinc per 100,000 grams of protein.
T M, Wandzilak, R W, Benson
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Mitogenic stimulation of transcription by RNA polymerase III
Biochemical Society Transactions, 2004Regulation of protein synthesis is an important aspect of growth control. RNA polymerase (pol) III plays a key role in this process by catalysing production of tRNA and 5 S rRNA. Growth factors trigger a rapid increase in pol III activity and this is essential for cell proliferation.
E, Mauger, P H, Scott
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Epigenetic regulation of transcription by RNA polymerase III
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2013Chromatin participates actively in all DNA transactions and all phenomena directly under the influence of chromatin are explained by epigenetic mechanisms. The genes transcribed by RNA polymerase (pol) III are generally found in regions free of nucleosomes, the structural units of chromatin.
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Unraveling the complexities of transcription by RNA polymerase III
Trends in Biochemical Sciences, 1990The biosynthesis of proteins and nucleic acids in eukaryotes requires the participation of numerous small RNAs, many of which are products of RNA polymerase III transcription. How cells are able to coordinate the synthesis of these RNAs during growth and replication has been the subject of recent exciting and thought-provoking studies.
J M, Palmer, W R, Folk
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TRANSCRIPTION BY RNA POLYMERASE III
Annual Review of Biochemistry, 1988E P, Geiduschek, G P, Tocchini-Valentini
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Transcription of Adenovirus RNA Polymerase III Genes
1995Eukaryotic RNA polymerase (RNAp) III is responsible for synthesis of abundant, low molecular mass RNA species, including tRNA, 5S rRNA, and U6 snRNA (see Roeder 1976; Geiduschek and Tocchini-Valentini 1988). Although they are noncoding, RNAp III transcripts participate in such essential processes as translation, RNA processing, and protein targeting ...
R, Pruzan, S J, Flint
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