Results 201 to 210 of about 587,888 (232)

Optimization and Validation of Universal Real-Time RT-PCR Assay to Detect Virulent Newcastle Disease Viruses. [PDF]

Viruses
Alexander Morris ER, Schroeder ME, Anderson PN, Schroeder LJ, Monday N, Senties-Cue G, Ficken M, Ferro PJ, Suarez DL, Dimitrov KM.   +9 more
europepmc   +1 more source

In situ profiling of plasma cell clonality with image-based single-cell transcriptomics

Yang E, Aceves-Salvador J, Castrillon C, Herrmann US, Akama-Garren EH, Carroll MC, Moffitt JR.   +6 more
europepmc   +1 more source

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Cotranscriptional RNA Chemical Probing

2022
Cotranscriptional folding is a fundamental step in RNA biogenesis and the basis for many RNA-mediated gene regulation systems. Understanding how RNA folds as it is synthesized requires experimental methods that can systematically identify intermediate RNA structures that form during transcription.
Courtney E, Szyjka, Eric J, Strobel
openaire   +2 more sources

RNA imaging by chemical probes

Advanced Drug Delivery Reviews, 2019
Sequence-specific detection of intracellular RNA is one of the most important approaches to understand life phenomena. However, it is difficult to detect RNA in living cells because of its variety and scarcity. In the last three decades, several chemical probes have been developed for RNA detection in living cells.
Fumiaki Tomoike, Hiroshi Abe
openaire   +3 more sources

Structural Probing of RNA Thermosensors

2009
Chemical probing of RNA structure has become one of the most popular approaches to map the conformation of RNA molecules of various sizes under well-defined experimental conditions. The method monitors the sensitivity of each nucleotide to various chemicals, which reflects its hydrogen-bonding environment within the RNA molecule.
Claude Chiaruttini, Mathias Springer, Frédéric Allem   +2 more
openaire   +4 more sources

Probing the RNA–protein interface

Nature Reviews Genetics, 2020
Corley et al. report fSHAPE, a simplified strategy for in vivo transcriptome-wide footprinting with SHAPE structure-probing techniques.
openaire   +3 more sources

Probing RNA Translocases with DNA

2014
For some helicases, it is possible to investigate RNA translocase activity on DNA substrates because the enzyme acts on both substrates. Potassium permanganate (KMnO4) footprinting is a method used to chemically probe the conformation of DNA as well as the binding of proteins.
Kimberly A. Reynolds, Kevin D. Raney, Veronica M. Raney   +2 more
openaire   +3 more sources

RNA Stable Isotope Probing (RNA-SIP)

2019
Stable isotope probing is a combined molecular and isotopic technique used to probe the identity and function of uncultivated microorganisms within environmental samples. Employing stable isotopes of common elements such as carbon and nitrogen, RNA-SIP exploits an increase in the buoyant density of RNA caused by the active metabolism and incorporation ...
Benjamin Moreira-Grez, Tim K. Morald, Andrew S. Whiteley, Noor Ul Huda Ghori, Paton Vuong, Ian Waite, Michael J. Wise   +6 more
openaire   +3 more sources

Chemical Probing of RNA and RNA/Protein Complexes

2009
Chemical probing is widely used as a rapid approach for assessing RNA structure, folding, and function. In this chapter, we outline procedures for handling and using chemicals commonly used to probe nucleic acids. Detailed experimental conditions and design for footprinting and modification interference are presented herein.
Zhili Xu, Gloria M. Culver
openaire   +3 more sources